Senior Medical Director, Rheumatology

Role Summary

Senior Medical Director in Clinical Development for rheumatology and autoimmune diseases. Involved across the full scope of clinical drug development from discovery research through first in human, proof-of-concept, and Phase 3 studies. Will lead one or more studies within the portfolio and collaborate with the cross-functional asset team to advance clinical programs and asset strategy. Location: South San Francisco, CA; onsite Tuesday–Thursday, open to remote applicants with monthly onsite requirement.

Responsibilities

• Serve as the physician lead for LUMUS, a 388-patient Phase 2b trial evaluating multiple doses of ESK-001 in adult patients with moderately to severely active, autoantibody-positive SLE.
• Provide leadership of in-stream data reviews and reconciliation efforts.
• Authorship of clinical portions of key study documents, including Protocol Amendments and Regulatory Submissions.
• Oversee the LUMUS medical monitor.
• Engage externally in scientific activities, including peer-to-peer interactions with MDs.
• Represent Alumis’ interests as a rheumatology leader and support corporate initiatives.
• Coach, manage, and support team members to achieve goals with a collaborative approach.
• Maintain high integrity and standards for scientific inquiry in drug development.
• Focus on hands-on leadership and collaboration with operations to drive program success and data quality.

Qualifications

• MD (or equivalent) with board certification in Rheumatology.
• 5+ years of clinical development experience; lupus clinical trials experience is preferred.
• Proven leadership experience, including managing people within industry or academic settings.
• Strong ability to assess, understand, and communicate evolving medical and scientific information.
• Track record of strategic, organizational, and executional skills to support multi-activity project planning and prioritization.
• Organized, detail-oriented, and capable of meeting timelines in fast-paced environments.
• Ability to work effectively across diverse, matrixed teams as both a leader and team member.
• Excellent interpersonal, influencing, presentation, and communication skills (written and verbal).
• Ability to work autonomously with a high level of independence.
• Willingness to travel to Alumis’ HQ in South San Francisco for one week per month.

Additional Requirements

• Location: South San Francisco, CA; onsite Tuesday–Thursday; remote applicants considered with monthly onsite requirement.