Senior Medical Director, Global Medical Affairs

Role Summary

Senior Medical Director, Global Medical Affairs for lonvoguran ziclumeran (lonvo-z/NTLA-2002) hereditary angioedema. Lead the development and execution of a US and global Medical Affairs strategy to support the launch of lonvo-z. Bring clinical and pharmaceutical industry experience, ideally in immunology, allergy, or rare diseases, with strong hereditary angioedema expertise. Drive cross-functional alignment of medical and commercial goals and deliver real-world evidence and medical education to customers and payers.

Responsibilities

• KOL Engagement Strategy (20%): Develop and drive a strategic engagement plan with key stakeholders including medical societies, payers, provider groups, and hereditary angioedema experts (US focus); build relationships with investigators, KOLs, research institutions, and centers of excellence to support HAE Medical Affairs objectives; collaborate with Patient Advocacy, Medical Engagement and Regional Scientific Directors to execute medical engagement strategy; plan and execute national and regional medical advisory boards; identify and prioritize thought leaders across geographies for global engagement topics.
• Real-world Evidence Generation (30%): Collaborate with Clinical Development and HEOR to ensure the integrated evidence plan aligns with lonvo-z HAE objectives; provide medical support for design and execution of research and translational analyses, post-hoc analyses, post-marketing studies, real-world studies, and claims analyses; work with Access & HEOR to support educational, engagement and evidence initiatives; develop real-world evidence strategies including registry design and observational research; design and execute investigator-led research; provide medical input for health economic modeling and value proposition development; contribute to payer and policy maker evidence dossiers.
• Internal Subject Matter Expert & Training Leadership (20%): Serve as primary in-house medical affairs SME on hereditary angioedema, CRISPR technology, and lonvo-z; oversee medical/legal review for commercial materials as needed (cMLR); deliver training programs for medical affairs, commercial, and market access teams; ensure medical accuracy and fair balance in educational materials for HCP audiences; contribute to scientific resources and competitive analyses; provide on-demand scientific consultation to cross-functional stakeholders; develop content and present at internal and external medical education programs.
• Healthcare Systems Strategy (20%): Serve as in-house SME on lonvo-z systems obligations and competencies; contribute to cross-functional teams preparing for post-marketing accessibility, including prescriber and system readiness; design and execute an evidence generation plan to understand the impact of a one-time treatment on overall healthcare system costs with Access/HEOR collaboration.
• Additional Responsibilities (10%): Support the Medical Affairs Lead for lonvo-z in short-term and long-term strategy and execution of the program medical affairs plan; participate in the Medical Access Commercialization team; collaborate with Scientific Communications on publications and resources to ensure medical accuracy and alignment; provide medical input into the safety profile in collaboration with Clinical Development and Patient Safety colleagues.

Qualifications

• Robust clinical research experience within the pharmaceutical/biotech industry.
• Experience within a medical affairs team with responsibility for late-stage clinical studies across multiple regions.
• Strong track record in KOL engagement strategy development and execution.
• Demonstrated experience leading and executing evidence generation initiatives.
• Proven ability to serve as SME and deliver impactful training programs.
• Solid communication, strategic, interpersonal, and negotiating skills; ability to proactively predict challenges and solve problems.
• Ability to drive decision-making within multi-disciplinary, multi-regional, matrix teams.
• Diplomacy and positive influencing abilities.
• Knowledge of regional and global regulatory requirements.
• Ability to present complex issues to management and contribute to executive-level presentations and discussions.
• Experience leading and motivating cross-functional teams and vendors/consultants.
• Excellent interpersonal skills with ability to respond to multiple external and internal queries and manage conflicts constructively.
• Proven success working in a fast-paced, matrixed, growing organization, partnering with multiple internal and external stakeholders.
• Experience in Medical Affairs leadership for products addressing rare diseases with strong therapeutic knowledge in hereditary angioedema, immunology, or related fields; familiarity with novel modalities (gene editing, CRISPR, genetic medicines) strongly preferred.
• Track record of successful research in therapeutic areas relevant to Intellia's development programs and pipeline.

Education

• MD/PharmD

Additional Requirements

• Physical requirements: ability to sit or stand for multiple hours at a computer; manual dexterity for keyboarding.
• Travel up to 40-50% for KOL meetings, conferences, and internal training sessions.