Senior/Medical Director

Vor Bio - Transforming Autoimmune Disease

Vor Bio is a clinical-stage biotechnology company transforming the treatment of autoimmune diseases. Our goal is to bring life-changing therapies to patients worldwide who are living with serious autoantibody-driven conditions. This dual-target mechanism reduces autoreactive B cells and autoantibody production, key drivers of autoimmune pathology.

We are advancing Telitacicept, a novel, dual-target recombinant fusion protein that inhibits both BLyS (BAFF) and APRIL—two key cytokines involved in B cell survival and autoantibody production. In a Phase 3 clinical trial in generalized myasthenia gravis in China, Telitacicept demonstrated a 4.8-point improvement in MG-ADL (Myasthenia Gravis Activities of Daily Living scale) vs. placebo at 24 weeks, the primary endpoint of the trial.

Telitacicept is approved in China for systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and generalized myasthenia gravis (gMG). A global Phase 3 clinical trial in gMG is currently underway across the United States, Europe, and South America to support potential approval in the United States and Europe.

We are looking for motivated Medical Directors/Sr. Medical Directors to join our growing global clinical development team.

Responsibilities:

• Provide medical and scientific leadership to clinical development strategies and protocol development.
• Lead execution of phase 2 and 3 clinical trials in collaboration with cross functional team including clinical operations, regulatory, pharmacovigilance, CMC, and other relevant functions.
• Ensure subject eligibility and monitor safety of subjects.
• Engage investigators and provide guidance on protocol design, procedures and patient recruitment and retention.
• Lead clinical portion of IND, IBs, CTAs, BLAs and other regulatory submissions.
• Authorship of abstracts, manuscripts for publication based on clinical trial results.
• Present data and scientific information to the organization at all levels.
• Building credible relationships with key opinion leaders and external alliances when relevant.
• May involve in business development opportunities.

Qualifications:

• MD degree required
• Board certification in Rheumatology or Neurology is highly desired
• A minimum of 5 years of clinical research experience.
• Clinical trial experience in autoimmune indications in an industry setting (eg, pharmaceutical, biotech, or CRO) is strongly preferred.
• Must be motivated, proactive, and have excellent communication skills.

By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We are conveniently located in Boston with easy access to public transportation and ample parking.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.