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Senior Manager – Response Threat Operations

Pfizer
September 04, 2026
Full-time
Remote friendly (Pennsylvania, United States)
Worldwide
IT
Role: Senior Manager leading Response Threat Operations within Pfizer's Cyber Defense team, focused on cybersecurity incident response, threat detection, and attack lifecycle analysis. Responsibilities include overseeing 24/7 threat monitoring, incident investigation, developing remediation strategies, and driving operational excellence through process optimization and automation. The role involves strategic leadership, talent management, and collaboration with Cyber Defense and CISO leadership to shape threat detection and response capabilities. Requirements: Bachelor's degree with 6+ years (or equivalent experience) in cybersecurity, with advanced knowledge of network protocols, attack TTPs, Windows OS, and security tools (Wireshark, Snort, Splunk, Kali Linux). Experience with scripting languages such as Python or C, and familiarity with digital forensics and malware analysis are essential. Candidates must demonstrate leadership, communication skills, and experience in an agile environment. High-Value specifics: cybersecurity incident response, threat lifecycle analysis, open-source security tools, cloud/hybrid environments, occasional travel (10-20%), hybrid work setup. The position reports to the Response Threat Operations team and involves managing a regional team, with a salary range of $139,100-$231,900, and includes benefits and performance-based incentives.