Senior Manager, PharmSci Clinical Manufacturing Planning
Takeda
August 22, 2026
On-site
Lexington, MA
$137,000 - $215,270 USD yearly
Operations
Objective/Purpose
- Own development and execution of program-level Drug Substance/Drug Product (DS/DP) production plans for clinical portfolio, aligning to demand, manufacturing constraints, and supply continuity.
- Translate cross-functional inputs into feasible, risk-managed, decision-ready plans for governance forums.
- Apply standardized planning rules and continuously improve planning practices.
Responsibilities
- Develop and maintain integrated DS/DP production plans for assigned programs/assets.
- Convert demand signals, technical inputs, and network constraints into production plans, scenarios, and inventory strategies.
- Create alternative scenarios to evaluate timing, capacity, inventory, and cost tradeoffs.
- Identify, quantify, and communicate supply risks and mitigation strategies; incorporate agreed actions.
- Align CMC, CDMO managers, and GCSC planners on assumptions, actions, and execution priorities.
- Prepare governance/escalation/decision-support materials.
- Monitor execution vs. plan; adjust proactively to maintain supply continuity.
- Drive adoption of standardized planning practices and continuous improvement.
Qualifications (Required/Preferred)
- Bachelor’s degree in Life Sciences/Engineering/Supply Chain/Operations/Pharmacy/Business or related discipline (advanced degree preferred).
- 6+ years relevant experience in pharma/biotech clinical manufacturing, supply planning, CMC, or contract manufacturing (preferred).
- Regulated-environment experience with production planning, supply scenarios, inventory strategies, and demand/supply balancing.
Skills
- DS/DP planning principles; scenario modeling; risk-based planning.
- GxP knowledge (GMP/GDP/GCP considerations).
- Strong analytical/quantitative, communication/presentation, and stakeholder management skills.
- Ability to manage multiple moderate-complexity projects simultaneously.
- Certifications (APICS/CPIM/CSCP, PMP, Lean, Six Sigma) preferred.
Benefits (if applicable per location)
- Eligible for medical/dental/vision, 401(k) match, disability, basic life, tuition reimbursement, paid volunteer time off, company holidays, well-being benefits; up to 80 hours sick time/year; up to 120 hours paid vacation on accrual.
Application Instructions
- Apply via the “Apply” button.
- Own development and execution of program-level Drug Substance/Drug Product (DS/DP) production plans for clinical portfolio, aligning to demand, manufacturing constraints, and supply continuity.
- Translate cross-functional inputs into feasible, risk-managed, decision-ready plans for governance forums.
- Apply standardized planning rules and continuously improve planning practices.
Responsibilities
- Develop and maintain integrated DS/DP production plans for assigned programs/assets.
- Convert demand signals, technical inputs, and network constraints into production plans, scenarios, and inventory strategies.
- Create alternative scenarios to evaluate timing, capacity, inventory, and cost tradeoffs.
- Identify, quantify, and communicate supply risks and mitigation strategies; incorporate agreed actions.
- Align CMC, CDMO managers, and GCSC planners on assumptions, actions, and execution priorities.
- Prepare governance/escalation/decision-support materials.
- Monitor execution vs. plan; adjust proactively to maintain supply continuity.
- Drive adoption of standardized planning practices and continuous improvement.
Qualifications (Required/Preferred)
- Bachelor’s degree in Life Sciences/Engineering/Supply Chain/Operations/Pharmacy/Business or related discipline (advanced degree preferred).
- 6+ years relevant experience in pharma/biotech clinical manufacturing, supply planning, CMC, or contract manufacturing (preferred).
- Regulated-environment experience with production planning, supply scenarios, inventory strategies, and demand/supply balancing.
Skills
- DS/DP planning principles; scenario modeling; risk-based planning.
- GxP knowledge (GMP/GDP/GCP considerations).
- Strong analytical/quantitative, communication/presentation, and stakeholder management skills.
- Ability to manage multiple moderate-complexity projects simultaneously.
- Certifications (APICS/CPIM/CSCP, PMP, Lean, Six Sigma) preferred.
Benefits (if applicable per location)
- Eligible for medical/dental/vision, 401(k) match, disability, basic life, tuition reimbursement, paid volunteer time off, company holidays, well-being benefits; up to 80 hours sick time/year; up to 120 hours paid vacation on accrual.
Application Instructions
- Apply via the “Apply” button.