Senior Manager MES System

At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference. Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact. We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together. Job Description Key Responsibilities Platform Ownership & Strategy Own the MES platform end-to-end, including PAS-X core, integrations, infrastructure, and supporting services. Define and execute the MES platform strategy aligned with site and enterprise manufacturing priorities. Establish and maintain a multi-year MES roadmap covering sustainment, modernization, scalability, and technical debt reduction. Serve as the single accountable decision owner for MES platform architecture, risk, and trade-offs. DevOps & Operational Excellence Own the DevOps operating model for MES, including incident, problem, change, release, and deployment management. Ensure high availability, performance, and reliability of MES in a 24x7 GMP manufacturing environment. Lead root cause analysis for critical incidents and drive systemic corrective and preventive actions. Oversee system upgrades, patches, enhancements, and infrastructure changes with minimal manufacturing disruption. Define and monitor operational SLAs, KPIs, and reliability metrics. Compliance, Validation & Quality Own the MES validation strategy (IQ/OQ/PQ) in alignment with GxP, GAMP 5, and 21 CFR Part 11 requirements. Ensure continuous inspection readiness through strong documentation, controls, and operating discipline. Partner with Quality to ensure compliance is embedded in solution design, delivery, and operations. Accountable for audit readiness, support, responses, observations, and remediation related to MES. Delivery & Continuous Improvement Govern intake, prioritization, and delivery of MES enhancements and business requests. Balance run and change demand to ensure predictable delivery without compromising system stability. Drive standardization, simplification, and reuse across MES workflows and configurations. Identify and sponsor opportunities for automation, analytics, and AI-enabled improvements. People Leadership Lead, coach, and develop a multi-disciplinary MES DevOps and development team. Set clear roles, expectations, and accountability across support, development, and delivery functions. Build team capability and resilience through succession planning, cross-training, and skills development. Foster a culture of ownership, quality, continuous improvement, and collaboration. Stakeholder & Financial Management Serve as a senior interface to Manufacturing, Packaging, Quality, Automation, Warehouse, and IT leadership. Translate business priorities into executable MES outcomes and investment decisions. Own and manage MES operating and project budgets, including forecasting and cost control. Provide concise executive-level communication on platform health, risks, and roadmap progress. Basic Qualifications Bachelor’s degree in IT, Engineering, Computer Science, or a related discipline (or equivalent experience). 10+ years of experience supporting or leading MES or manufacturing systems in a regulated (GxP) environment. Demonstrated experience owning and operating mission-critical platforms in a 24x7 environment. Proven people management experience leading technical teams. Strong working knowledge of PAS-X MES platforms. Preferred Qualifications Experience establishing DevOps or product-centric operating models in regulated manufacturing. Direct accountability for audits, inspections, and regulatory interactions related to MES. Experience managing both run and change budgets for large enterprise platforms. Knowledge of SAP–MES integration, ISA-95 / S88, and OT/automation interfaces. Certification in PAS-X MES systems. Experience with leveraging AI/ML. Strong executive communication and stakeholder management skills. Location: La Verne, CA The salary range for this position is: $153,935.00 - $199,210.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing * Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. For jobs in the United States: Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance. For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster. NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team. Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion. For Current Gilead Employees and Contractors: Please apply via the Internal Career Opportunities portal in Workday. Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.