Senior Manager: Manufacturing - Upstream

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Amgen, a global biotechnology leader, is investing $1 billion to expand in Holly Springs, North Carolina, by adding a second drug substance biomanufacturing plant. This brings the total site investment to over $1.5 billion, building on the initial $550 million that launched the first plant. The site will feature two manufacturing facilities, warehouse space, central utilities, and offices, generating around 725 skilled jobs and fostering a culture of diversity, inclusion, and belonging.

Join Amgen’s most advanced drug substance manufacturing facility. The FleX Batch facility and its two manufacturing plants will blend the latest in single-use technologies with traditional stainless-steel equipment, delivering maximum operational flexibility. It will incorporate cutting-edge manufacturing technologies and embedded Industry 4.0 capabilities for greater efficiency and adaptability. Sustainability is also central—innovations will reduce carbon emissions and waste, supporting Amgen’s goal to be carbon-neutral by 2027.

The first plant is expected to be operational in 2025, with construction of the second beginning the same year and operations starting in 2028. This is an exciting chance for individuals eager to build from the ground up, develop talent, and help shape the future of sustainable biomanufacturing.

Senior Manager: Manufacturing - Upstream

What You Will Do

Let’s do this. Let’s change the world. As a Senior Manager of Manufacturing for our second plant, you will provide leadership and guidance to the team responsible for 24/7 manufacturing operations in the Manufacturing Upstream Cell Culture area, which includes the following responsibilities: Cell Expansion, Seed Train Operations, Production Bioreactors, Harvest Operations, and associated Equipment Preparation and Turnaround.

In this vital role as a member of the Manufacturing leadership team you will work hand in hand with a multidisciplinary team to deliver robust equipment, procedures, and processes to operate the new plant. This includes organizational design, hiring, and training of the staff required to support start up and operations of the plant and oversight of operational readiness initiatives for the area.

• Build, develop, and retain a diverse and high performing team in alignment with operational readiness schedules to ensure successful startup and transition to GMP operations
• Be responsible for the safety and quality culture of the department and champion continued improvement
• Effectively collaborate with manufacturing support groups (Quality, Process Development, Engineering, Supply Chain, and network partners)
• Provide support to troubleshoot, identify, and resolve issues as needed and manage call coverage for 24/7 operation
• Provide technical leadership for the investigation of deviations and the development of corrective actions
• Develop and implement departmental strategy and plans that are aligned with the broader organizational strategy and deliver continuous improvement
• Lead and support regulatory inspections for areas of responsibilities including evaluating complex compliance issues and developing playbooks for the inspections
• Deliver against organizational financial commitments while championing a lean philosophy

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The experienced professional we seek is a collaborative partner with these qualifications.

Basic Qualifications:

• High School diploma/GED and 12 years of Manufacturing & Operations experience OR
• Associate's degree and 10 years of Manufacturing & Operations experience OR
• Bachelor’s degree and 8 years of Manufacturing & Operations experience OR
• Master’s degree and 6 years of Manufacturing & Operations experience OR
• Doctorate degree and 2 years of Manufacturing & Operations experience OR
• AND in addition to meeting at least one of the above requirements, you must have a minimum of 2 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources. Your managerial experience may run concurrently with the required technical experience referenced above

Preferred Qualifications:

• Demonstrated managerial experience in a GMP manufacturing drug substance plant
• Demonstrated experience in applying Operational Excellence and Lean Manufacturing
• Cross-functional work experience in either Process Development, Quality or Engineering
• Excellent communication skills, drive, sense of urgency, energy level and problem-solving abilities
• Demonstrated ability to forge and maintain strong relationships with other functional areas
• Ability to effectively develop and coach staff and positively advance the culture of an organization

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Apply now and make a lasting impact with the Amgen team.

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As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.