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Senior Manager, Global Medical Affairs Strategy, RNA Therapeutics

Sarepta Therapeutics
September 26, 2026
Full-time
Remote friendly (Colorado, United States)
Worldwide
Medical Affairs
Role: Senior Manager, Global Medical Affairs Strategy for RNA Therapeutics at Sarepta, focusing on supporting the development and lifecycle management of siRNA therapies for neuromuscular and related rare diseases. Responsibilities include developing medical strategies aligned with product launches and lifecycle needs, identifying data gaps, generating supportive scientific narratives, analyzing clinical and real-world data, and contributing to congress and advisory board content. The role involves cross-functional collaboration, training, and managing medical content, vendor guidance, and regulatory review processes. The position emphasizes building expertise in DMD and siRNA within Sarepta, staying current with scientific developments, and representing medical affairs in cross-functional teams. Requirements: MD, PhD, or PharmD with 3+ years in pharma, preferably in rare diseases or neuromuscular disorders. Skills include strategic thinking, collaboration, independent problem-solving, project management, and excellent communication. Travel both domestic and international required. Work setup is hybrid, based in the U.S., with occasional in-person events. The role is critical for shaping Sarepta’s scientific messaging, data analysis, and medical strategy execution in the gene therapy landscape for Duchenne muscular dystrophy and related indications.