Senior Manager, Clinical Operations
Travere Therapeutics
August 29, 2026
Remote friendly (San Diego Metropolitan Area)
United States
Clinical Research and Development
Position Summary:
The Senior Manager, Clinical Operations is responsible for supervision and execution of clinical operations for Phase 1–3 clinical trials, coordinating daily trial activities with the internal project team and CROs.
Responsibilities:
- Provide daily oversight of internal study teams, full-service CROs, clinical sites, and third-party vendors.
- Triage, resolve, or escalate study issues to Clinical Operations Management.
- Evaluate unpredictable scenarios to achieve project timelines using understanding of study protocols.
- Manage assigned area/study(s) including program timeline, budgets, and the Study Management Team (SMT); ensure on-time milestone delivery.
- Guide cross-functional activities (e.g., Biometrics, PV) to ensure execution per study plans, SOPs, and ICH/GCP.
- Track study status, timelines, enrollment, regulatory documentation, and site start-up status.
- Develop/provide input into clinical study documents and site-facing materials.
- Oversee CRO/vendor budgets and forecast changes with Strategic Procurement.
- Track/manage trial-related materials, supplies, and lab samples.
- Lead cross-functional activities to establish and meet SMT goals; communicate issues/mitigations.
- Provide basic strategic input into study management.
Qualifications (Education/Experience):
- Bachelor’s degree (or equivalent combination).
- 7+ years clinical trial experience; 2+ years managing clinical studies at sponsor or CRO.
- Global regulatory/compliance experience (US CFR, EU CTD, ICH E6(R2) GCP).
- Phase 1–3 study experience preferred (including international studies).
Additional Skills/Experience:
- Courage, Community Spirit, Patient Focus, Teamwork.
- Proactive self-starter; ability to set goals and execute on timelines.
- Independently identify issues, determine cause, and propose/implement solutions.
- Strong written/oral communication; present cross-functional updates.
- Advanced problem-solving/critical thinking; urgency and attention to detail.
- Proficiency in MS Office and timeline tools (MS Project/Smartsheet); experience with IRT, eTMF.
- Record of managing complex plans/timelines/budgets.
- Travel 10–20%.
Benefits:
- Comprehensive benefits including premium health, life insurance, disability, retirement with match, and generous paid time off.
Compensation:
- Target base pay range: $132,000–$172,000.
Application instructions:
- Apply on an ongoing basis until a candidate is selected.
The Senior Manager, Clinical Operations is responsible for supervision and execution of clinical operations for Phase 1–3 clinical trials, coordinating daily trial activities with the internal project team and CROs.
Responsibilities:
- Provide daily oversight of internal study teams, full-service CROs, clinical sites, and third-party vendors.
- Triage, resolve, or escalate study issues to Clinical Operations Management.
- Evaluate unpredictable scenarios to achieve project timelines using understanding of study protocols.
- Manage assigned area/study(s) including program timeline, budgets, and the Study Management Team (SMT); ensure on-time milestone delivery.
- Guide cross-functional activities (e.g., Biometrics, PV) to ensure execution per study plans, SOPs, and ICH/GCP.
- Track study status, timelines, enrollment, regulatory documentation, and site start-up status.
- Develop/provide input into clinical study documents and site-facing materials.
- Oversee CRO/vendor budgets and forecast changes with Strategic Procurement.
- Track/manage trial-related materials, supplies, and lab samples.
- Lead cross-functional activities to establish and meet SMT goals; communicate issues/mitigations.
- Provide basic strategic input into study management.
Qualifications (Education/Experience):
- Bachelor’s degree (or equivalent combination).
- 7+ years clinical trial experience; 2+ years managing clinical studies at sponsor or CRO.
- Global regulatory/compliance experience (US CFR, EU CTD, ICH E6(R2) GCP).
- Phase 1–3 study experience preferred (including international studies).
Additional Skills/Experience:
- Courage, Community Spirit, Patient Focus, Teamwork.
- Proactive self-starter; ability to set goals and execute on timelines.
- Independently identify issues, determine cause, and propose/implement solutions.
- Strong written/oral communication; present cross-functional updates.
- Advanced problem-solving/critical thinking; urgency and attention to detail.
- Proficiency in MS Office and timeline tools (MS Project/Smartsheet); experience with IRT, eTMF.
- Record of managing complex plans/timelines/budgets.
- Travel 10–20%.
Benefits:
- Comprehensive benefits including premium health, life insurance, disability, retirement with match, and generous paid time off.
Compensation:
- Target base pay range: $132,000–$172,000.
Application instructions:
- Apply on an ongoing basis until a candidate is selected.