Senior Manager, Clinical Data Management

Role Summary

Reporting to the Associate Director of Clinical Data Management, the Senior Manager of Clinical Data Management will be responsible for managing clinical data management activities across Tango’s clinical trials. This includes overseeing study-specific data management processes from trial planning through database lock. This role involves collaborating with cross-functional teams and external partners to ensure high-quality, timely clinical data, supporting the operational execution of clinical trials.

Responsibilities

• Serve as the lead data management representative on cross-functional study teams
• Manage day-to-day clinical data management activities with CROs and vendors to ensure timely and accurate data capture
• Develop, review, and maintain study-specific data management documentation, including Data Management Plans (DMPs), CRF Completion Guidelines, and Data Review Guidelines
• Provide leadership and oversight for user acceptance testing (UAT) of eCRFs and associated edit checks
• Guide and monitor data cleaning, discrepancy management, and data reconciliation activities with external vendors and internal stakeholders
• Establish, review and monitor data quality metrics to ensure clean, consistent, and analyzable datasets
• Partner with CROs to manage timelines and deliverables for data management activities
• Contribute to database lock activities, ensuring audit readiness and data integrity
• Maintain and ensure accuracy of study-specific trackers and metrics dashboards
• Create and manage data deliverable timelines and tasks
• Review and provide feedback on vendor data transfer agreements, transfers and reconciliation

Qualifications

• BS with 5+ years of clinical data management experience in CRO, pharma, or biotech settings
• Strong experience with Medidata Rave EDC systems and electronic trial master files (eTMF)
• Demonstrated knowledge of ICH/GCP, FDA regulations, and clinical trial processes
• Proficiency in industry data standards including CDISC, SDTM, and CDASH
• Prior experience collaborating with CROs on clinical studies
• Highly organized with excellent communication and interpersonal skills
• Experience in small biotech environments highly preferred
• Familiarity with data visualization or analytics tools such as R, SAS or elluminate
• Cross collaboration proficiency with other related functions such as Biostatistics, Statistical Programming, and Pharmacovigilance
• Understanding of FDA and ICH GCP guidelines to ensure appropriate reporting of clinical trial data
• Ability to manage multiple projects in a fast-paced environment

Skills

• Clinical data management leadership
• Data quality management
• Vendor and CRO coordination
• eCRF/UAT oversight
• Data standards (CDISC, SDTM, CDASH)
• Medidata Rave and eTMF proficiency
• Project management

Education

• BS degree (required)

Additional Requirements

• None specified