Senior Expert Science & Technology - Mass Spectrometry - Gene Therapy Analytical Development - Chemistry
Novartis
August 30, 2026
On-site
East Hanover, NJ
Clinical Research and Development
Role Purpose
- Support analytical development activities to characterize gene therapy products, leveraging mass spectrometry for cross-functional process/product monitoring and continuous improvement.
Key Responsibilities
- Design, plan, and perform protein mass spectrometry product characterization studies; optimize/implement analyses including peptide mapping (PTMs), intact/middle-down MS (variants), and quantitation (TMT labeling, label-free).
- Apply chromatography (HPLC), capillary electrophoresis (CE), and biophysical assays for characterization and lot release/stability monitoring.
- Drive project/network strategy; apply scientific/technical/GMP/quality expertise to solve complex R&D issues.
- Coach team members; maintain/qualify equipment/infrastructure and manage lab operations as assigned.
- Identify, develop, validate, and implement novel analytical assays and new GMP-compliant methods for pipeline gene therapy products.
- Meet project timelines and deliverables with internal quality and data integrity requirements.
- Resolve technical challenges and communicate/present complex data cross-functionally.
- Author/review method development reports, SOPs, validation reports, and technical documents for regulatory filings.
- Advance analytical development for clinical and commercial manufacturing; identify new technologies/instrumentation.
Essential Requirements
- BS in relevant field with >5 years industry required (preferred: BS >6, MS >4, PhD >2).
- Expertise in protein mass spectrometry and related disciplines; AAV/LVV analytics preferred.
- High-resolution MS required; Thermo Tribrid MS valued.
- Analytical software: Byos, Proteome Discoverer, BioPharmaFinder, Xcalibur; chromatography systems tools (Chromeleon, Empower, Chemstation, 32Karat) knowledge.
- Strong background in gene therapy, cell biology, and drug product development; collaborative, fast-paced learning ability.
Compensation/Benefits (as stated)
- Pay range: $108,500–$201,500/year; total compensation may include sign-on bonus, RSUs, discretionary awards, and medical/financial benefits (including 401(k) and paid time off).
- Support analytical development activities to characterize gene therapy products, leveraging mass spectrometry for cross-functional process/product monitoring and continuous improvement.
Key Responsibilities
- Design, plan, and perform protein mass spectrometry product characterization studies; optimize/implement analyses including peptide mapping (PTMs), intact/middle-down MS (variants), and quantitation (TMT labeling, label-free).
- Apply chromatography (HPLC), capillary electrophoresis (CE), and biophysical assays for characterization and lot release/stability monitoring.
- Drive project/network strategy; apply scientific/technical/GMP/quality expertise to solve complex R&D issues.
- Coach team members; maintain/qualify equipment/infrastructure and manage lab operations as assigned.
- Identify, develop, validate, and implement novel analytical assays and new GMP-compliant methods for pipeline gene therapy products.
- Meet project timelines and deliverables with internal quality and data integrity requirements.
- Resolve technical challenges and communicate/present complex data cross-functionally.
- Author/review method development reports, SOPs, validation reports, and technical documents for regulatory filings.
- Advance analytical development for clinical and commercial manufacturing; identify new technologies/instrumentation.
Essential Requirements
- BS in relevant field with >5 years industry required (preferred: BS >6, MS >4, PhD >2).
- Expertise in protein mass spectrometry and related disciplines; AAV/LVV analytics preferred.
- High-resolution MS required; Thermo Tribrid MS valued.
- Analytical software: Byos, Proteome Discoverer, BioPharmaFinder, Xcalibur; chromatography systems tools (Chromeleon, Empower, Chemstation, 32Karat) knowledge.
- Strong background in gene therapy, cell biology, and drug product development; collaborative, fast-paced learning ability.
Compensation/Benefits (as stated)
- Pay range: $108,500–$201,500/year; total compensation may include sign-on bonus, RSUs, discretionary awards, and medical/financial benefits (including 401(k) and paid time off).