Senior/Executive Director, Reverse Translation, Oncology Translational Research

Role: Senior/Executive Director of Reverse Translation in Oncology Translational Research, leading a laboratory-based team to investigate mechanisms of drug action, resistance, and combination strategies across the oncology spectrum. Responsibilities: drive mechanistic studies, develop hypotheses from clinical observations, design combination and resistance-reversal strategies, consolidate and lead a multidisciplinary lab platform (omics, functional biology, organoid models), and serve as a key scientific interface with discovery, medical affairs, and commercial teams. Participate in strategic planning, mentor scientists, and contribute to publications. Requirements: PhD, MD, or MD/PhD in relevant fields; 10+ years (Senior Director) or 12+ years (Executive Director) in oncology discovery or translational research with hands-on lab leadership; proven expertise in MOA/MOR, multiomics, and functional biology; strong publication record and cross-functional collaboration experience. Preferred: proficiency in multiomics, computational biology, organoid models, and portfolio mining; experience in combination and resistance strategies. High-Value: Oncology (solid and hematologic), reverse translation, drug mechanism, resistance, combination strategies, early-stage to clinical development, cross-functional leadership, and strategic lab management. Location: Spring House, PA; Cambridge, MA; San Diego, CA with potential for cross-site collaboration.