Senior Engineer II, mRNA Process Development

Role: Senior Engineer II leading the technical development of non-viral gene editing mRNA therapeutics at CRISPR Therapeutics. Primary objectives include designing, optimizing, and scaling-up upstream and downstream manufacturing processes, ensuring quality, and supporting clinical supply. Responsibilities involve process development using DoE and statistical analysis, tech transfer to GMP manufacturing, troubleshooting, and cross-functional collaboration with research, analytical, and manufacturing teams. The role also entails authoring technical documentation and mentoring junior staff. Qualifications: Ph.D. in Chemical Engineering, Bioengineering, Biochemistry, or related with 2-4.5+ years industry experience, or 10-12 years relevant non-PhD experience. Deep expertise in in vitro transcription, plasmid linearization, purification techniques (e.g., chromatography, TFF), and equipment operation (ÄKTA systems). Proficiency in statistical software (JMP, Minitab). Preferred: experience with mRNA-LNP formulations, GMP, and regulatory documentation. The position requires on-site work in a highly regulated GxP environment, with a focus on gene editing modalities for indications like sickle cell disease or beta thalassemia, at clinical development stages. The candidate should demonstrate collaboration, results orientation, entrepreneurial spirit, and a proactive approach.