Senior Director, US Payer Medical Affairs & Outcomes Strategy

Role Summary

The Senior Director, US Payer Medical Affairs & Outcomes Strategy reports to the Vice President of US Medical Affairs, TTR, with dual accountability across Medical Director Leadership and Field Team Leadership. The role leads the US Payer Ecosystem Medical Plan, real-world evidence strategy, and payer-focused research collaborations, and oversees the US Payer MOSL team to execute payer initiatives. This position is virtual and US-field based.

Responsibilities

• US Payer Medical Director Accountabilities (50%)
  • Lead the US Payer Ecosystem Medical Plan in alignment with brand, evidence generation, and access strategies.
  • Develop and implement a real-world payer evidence strategy that includes payer-driven research collaborations, pragmatic pilots, and data partnerships to address evidence needs for access and reimbursement.
  • Serve as the primary scientific and clinical point of contact for US payer stakeholders, including PBMs, MCOs, IDNs, and state Medicaid programs.
  • Collaborate with Health Economics & Outcomes Research (HEOR), Value & Access, and Policy teams to ensure payer evidence needs are incorporated into US and global evidence plans.
  • Shape and lead strategic payer-focused research collaborations, ensuring alignment with both scientific rigor and payer decision-making needs.
  • Act as a thought leader in payer-focused evidence generation, representing Alnylam in external forums and advancing partnerships with US healthcare systems.
• US Payer MOSL Team Leadership (50%)
  • Lead and manage the US Payer MOSL organization, ensuring execution of strategy with excellence and consistency across regions.
  • Translate payer evidence needs into actionable MOSL field engagement strategies, aligning account planning with corporate medical objectives.
  • Provide coaching, development, and performance oversight for MOSLs, fostering a culture of accountability, collaboration, and innovation.
  • Partner closely with National Accounts, Market Access, and US Medical leadership to deliver an integrated field medical strategy across payer segments.
  • Ensure strict compliance with all applicable PhRMA Codes, FDA laws, regulations, and company policies.
  • Champion cross-functional collaboration to align payer field activities with corporate priorities and ensure seamless execution.

Qualifications

• 10+ years of experience in Medical Affairs, HEOR, or payer-focused functions within biopharma/healthcare.
• Required: Experience either at a US payer organization (e.g., MCO, PBM, Medicaid/Medicare, IDN) or within the pharmaceutical/biotech industry leading US payer medical and evidence strategy.
• Advanced degree in life sciences (MD, DO, PharmD, PhD) strongly preferred.
• Proven experience developing and executing payer medical strategies and real-world evidence initiatives.
• Deep understanding of the US payer landscape, including policy, access drivers, and evidence requirements.
• Demonstrated leadership experience managing field medical teams or payer-facing medical organizations.
• Excellent scientific communication skills with ability to engage credibly with payer medical directors, pharmacy directors, and value committees.
• Strong organizational and strategic planning skills, with a track record of leading cross-functional initiatives.
• Ability to travel up to 50%.

Skills

• Scientific communication
• Cross-functional collaboration
• Strategic planning
• Leadership and people management
• Stakeholder engagement with payer organizations

Education

• Advanced degree in life sciences (MD, DO, PharmD, PhD) strongly preferred.

Additional Requirements

• Ability to travel up to 50%.