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Senior Director, US Payer Medical Affairs & Outcomes Strategy

Alnylam Pharmaceuticals
Remote friendly (United States)
United States
Medical Affairs

Role Summary

The Senior Director, US Payer Medical Affairs & Outcomes Strategy role is virtual with US-field based responsibilities. This position reports to the Vice President of US Medical Affairs, TTR, and holds dual accountability across two domains: Medical Director Leadership (50%) and Field Team Leadership (50%). The role involves designing and executing the US Payer Ecosystem Medical Plan, including real-world evidence strategy and payer collaborations, and leading the US Payer MOSL team to advance payer-focused initiatives.

Responsibilities

  • Lead the US Payer Ecosystem Medical Plan in alignment with brand, evidence generation, and access strategies.
  • Develop and implement a real-world payer evidence strategy that includes payer-driven research collaborations, pragmatic pilots, and data partnerships to address evidence needs for access and reimbursement.
  • Serve as the primary scientific and clinical point of contact for US payer stakeholders, including PBMs, MCOs, IDNs, and state Medicaid programs.
  • Collaborate with Health Economics & Outcomes Research (HEOR), Value & Access, and Policy teams to ensure payer evidence needs are incorporated into US and global evidence plans.
  • Shape and lead strategic payer-focused research collaborations, ensuring alignment with both scientific rigor and payer decision-making needs.
  • Act as a thought leader in payer-focused evidence generation, representing the company in external forums and advancing partnerships with US healthcare systems.
  • Lead and manage the US Payer MOSL organization, ensuring execution of strategy with excellence and consistency across regions.
  • Translate payer evidence needs into actionable MOSL field engagement strategies, aligning account planning with corporate medical objectives.
  • Provide coaching, development, and performance oversight for MOSLs, fostering a culture of accountability, collaboration, and innovation.
  • Partner closely with National Accounts, Market Access, and US Medical leadership to deliver an integrated field medical strategy across payer segments.
  • Ensure strict compliance with all applicable PhRMA Codes, FDA laws, regulations, and company policies.
  • Champion cross-functional collaboration to align payer field activities with corporate priorities and ensure seamless execution.

Qualifications

  • 10+ years of experience in Medical Affairs, HEOR, or payer-focused functions within biopharma/healthcare.
  • Required: Experience either at a US payer organization (e.g., MCO, PBM, Medicaid/Medicare, IDN) or within the pharmaceutical/biotech industry leading US payer medical and evidence strategy.
  • Advanced degree in life sciences (MD, DO, PharmD, PhD) strongly preferred.
  • Proven experience developing and executing payer medical strategies and real-world evidence initiatives.
  • Deep understanding of the US payer landscape, including policy, access drivers, and evidence requirements.
  • Demonstrated leadership experience managing field medical teams or payer-facing medical organizations.
  • Excellent scientific communication skills with ability to engage credibly with payer medical directors, pharmacy directors, and value committees.
  • Strong organizational and strategic planning skills, with a track record of leading cross-functional initiatives.
  • Ability to travel up to 50%.