Senior Director, Solid Tumor Asset Lead, Translational Development
Bristol Myers Squibb
5 days ago
Remote friendly (Princeton, NJ)
United States
Clinical Research and Development
Position Summary
The Asset Lead role will be responsible for development and execution of translational strategies in solid tumor oncology for assigned programs. Key responsibilities include acting as lead scientist to implement and generate innovative biomarker strategies for clinical programs (patient selection, differentiation, resistance, combinations, and indication selection). Develop translational reports/publications to support asset development and contribute to regulatory submissions. Work on cross-functional teams with disease/lab scientists and BMS stakeholders (clinical, medical, commercial, regulatory, diagnostics), and engage external academic collaborators/KOLs.
Key Responsibilities
- Integrate translational research and clinical development to develop biomarker strategies aligned to clinical objectives; lead data generation/interpretation and communication.
- Partner internally/externally to coordinate execution of translational development deliverables.
- Develop/champion/implement/align biomarker strategies with R&D portfolio goals.
- Define, revise, and progress translational biomarker plans with teams and matrix leadership.
- Analyze progress and apply critical thinking/problem-solving for key data/interpretations.
- Deliver biomarker strategies for mechanism of action/resistance, target engagement, pharmacodynamics endpoints, and patient selection.
- Ensure biomarker plan outputs meet project standards.
- Align biomarker strategies with clinical operational plans and capabilities to deliver translational biomarker data packages to support trials/programs.
- Manage communication of risks, milestones, and information flow across teams.
Qualifications & Experience
- Ph.D. in Oncology/Hematology (or related) with 12+ years industry experience, including significant translational experience.
- Comprehensive knowledge of drug discovery/clinical development methodologies.
- Strong understanding of translational research/medicine and clinical biomarkers in drug development.
- Demonstrated oncology/tumor-immunology disease biology knowledge.
- Preferably knowledge of modality-agnostic therapies (small molecules/biologics).
- Strong solid tumor oncology understanding and current clinical landscape knowledge.
- Proven impact using clinical/translational/mechanistic data; early/late-stage translational development experience; successful biomarker strategy implementation.
- Clinical protocol authoring and regulatory document review experience.
- Working knowledge of biomarker platforms (e.g., genomics, gene expression, immune profiling, flow cytometry).
- Excellent data analysis/problem-solving; exceptional written/verbal communication; publication and IND/NDA submission experience.
- Proven scientific/project leadership and experience leading global teams/external collaborations.
- Experience interacting with health authorities; ability to influence stakeholders.
The Asset Lead role will be responsible for development and execution of translational strategies in solid tumor oncology for assigned programs. Key responsibilities include acting as lead scientist to implement and generate innovative biomarker strategies for clinical programs (patient selection, differentiation, resistance, combinations, and indication selection). Develop translational reports/publications to support asset development and contribute to regulatory submissions. Work on cross-functional teams with disease/lab scientists and BMS stakeholders (clinical, medical, commercial, regulatory, diagnostics), and engage external academic collaborators/KOLs.
Key Responsibilities
- Integrate translational research and clinical development to develop biomarker strategies aligned to clinical objectives; lead data generation/interpretation and communication.
- Partner internally/externally to coordinate execution of translational development deliverables.
- Develop/champion/implement/align biomarker strategies with R&D portfolio goals.
- Define, revise, and progress translational biomarker plans with teams and matrix leadership.
- Analyze progress and apply critical thinking/problem-solving for key data/interpretations.
- Deliver biomarker strategies for mechanism of action/resistance, target engagement, pharmacodynamics endpoints, and patient selection.
- Ensure biomarker plan outputs meet project standards.
- Align biomarker strategies with clinical operational plans and capabilities to deliver translational biomarker data packages to support trials/programs.
- Manage communication of risks, milestones, and information flow across teams.
Qualifications & Experience
- Ph.D. in Oncology/Hematology (or related) with 12+ years industry experience, including significant translational experience.
- Comprehensive knowledge of drug discovery/clinical development methodologies.
- Strong understanding of translational research/medicine and clinical biomarkers in drug development.
- Demonstrated oncology/tumor-immunology disease biology knowledge.
- Preferably knowledge of modality-agnostic therapies (small molecules/biologics).
- Strong solid tumor oncology understanding and current clinical landscape knowledge.
- Proven impact using clinical/translational/mechanistic data; early/late-stage translational development experience; successful biomarker strategy implementation.
- Clinical protocol authoring and regulatory document review experience.
- Working knowledge of biomarker platforms (e.g., genomics, gene expression, immune profiling, flow cytometry).
- Excellent data analysis/problem-solving; exceptional written/verbal communication; publication and IND/NDA submission experience.
- Proven scientific/project leadership and experience leading global teams/external collaborations.
- Experience interacting with health authorities; ability to influence stakeholders.