Senior Director (Senior Principal Scientist), Translational Medicine, Immunology
Merck
12 days ago
Remote friendly (Boston, MA)
United States
Clinical Research and Development
Senior Principal Scientist (Senior Medical Director) Translational Medicine, Immunology
Translational Medicine is responsible for translating preclinical discovery into compounds ready for assessment in large clinical populations.
Responsibilities
- Partner with discovery research teams to contribute clinical insight to early target identification/validation and execute studies to evaluate target relevance to human disease.
- Develop biomarker strategies from First-in-Human through clinical Proof-of-Concept, including Experimental Medicine studies to establish/validate biomarker platforms.
- Develop and execute early clinical development strategy for Immunology programs (Preclinical Candidate through Phase 2a) and clinical pharmacology strategies for late-stage programs (Phase 2a through worldwide marketing application).
- Lead studies to validate clinical platforms using established/novel biomarkers (including imaging) to interrogate biological activity.
- Provide clinical expertise for novel target identification/validation, designing preclinical/clinical pharmacology experiments.
- Safely and timely execute Phase I studies and collaborate with cross-functional teams (discovery, biostatistics, DMPK, modeling/simulation, regulatory, and clinical operations).
- Provide clinical pharmacology support for worldwide marketing application filings.
- Communicate/interpret study results for governance and review committees.
- Assess internal/external opportunities identified by Business Development and Licensing.
Position Qualifications
- MD or MD/PhD.
- At least 5 years pharmaceutical industry experience in clinical research (preferably Immunology/translational).
Required Experience/Skills
- Proven clinical research track record in pharma.
- Proven clinical care or clinical problem-solving management experience (preferably Dermatology).
- Demonstrated scientific scholarship; immunology research expertise preferred.
- Strong interpersonal, writing, and presentation skills; ability to work in teams.
- Board Certification/Eligibility preferred.
Required skills: Academic Research, Clinical Studies, Clinical Trial Development, Dermatology, Drug Development, Gastroenterology, Immunology, Intellectual Curiosity, Pharmaceutical Research, Rheumatology, Scientific Publications/Research, Translational Research.
Application instructions
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees).
Translational Medicine is responsible for translating preclinical discovery into compounds ready for assessment in large clinical populations.
Responsibilities
- Partner with discovery research teams to contribute clinical insight to early target identification/validation and execute studies to evaluate target relevance to human disease.
- Develop biomarker strategies from First-in-Human through clinical Proof-of-Concept, including Experimental Medicine studies to establish/validate biomarker platforms.
- Develop and execute early clinical development strategy for Immunology programs (Preclinical Candidate through Phase 2a) and clinical pharmacology strategies for late-stage programs (Phase 2a through worldwide marketing application).
- Lead studies to validate clinical platforms using established/novel biomarkers (including imaging) to interrogate biological activity.
- Provide clinical expertise for novel target identification/validation, designing preclinical/clinical pharmacology experiments.
- Safely and timely execute Phase I studies and collaborate with cross-functional teams (discovery, biostatistics, DMPK, modeling/simulation, regulatory, and clinical operations).
- Provide clinical pharmacology support for worldwide marketing application filings.
- Communicate/interpret study results for governance and review committees.
- Assess internal/external opportunities identified by Business Development and Licensing.
Position Qualifications
- MD or MD/PhD.
- At least 5 years pharmaceutical industry experience in clinical research (preferably Immunology/translational).
Required Experience/Skills
- Proven clinical research track record in pharma.
- Proven clinical care or clinical problem-solving management experience (preferably Dermatology).
- Demonstrated scientific scholarship; immunology research expertise preferred.
- Strong interpersonal, writing, and presentation skills; ability to work in teams.
- Board Certification/Eligibility preferred.
Required skills: Academic Research, Clinical Studies, Clinical Trial Development, Dermatology, Drug Development, Gastroenterology, Immunology, Intellectual Curiosity, Pharmaceutical Research, Rheumatology, Scientific Publications/Research, Translational Research.
Application instructions
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees).