Senior Director, Project Management
IDEAYA Biosciences
August 17, 2026
Remote friendly (South San Francisco, CA)
United States
Operations
What you’ll do:
Strategic Program Leadership
- Serve as Project Manager for IDE892, owning overall program strategy with the Clinical Lead and Head of Research
- Integrate scientific, clinical, regulatory, and commercial perspectives into a Development Plan and Target Product Profile (TPP)
- Lead scenario planning, portfolio prioritization, and trade-off analyses for Senior Leadership and the Board
- Serve as key point of contact for the Roche collaboration on IDE892 (Joint Steering Committee prep and cross-company alignment)
- Anticipate strategic inflection points (combination selection, indication prioritization, registrational entry)
Operational Execution
- Own and maintain IDE892 integrated program timeline, critical path, milestone tracking, and risk register
- Lead cross-functional Program Team meetings; drive decisions, document outcomes, and ensure accountability
- Partner with Clinical Operations to oversee study execution across IDE892-001 cohorts, including RAS combination arms and expansion into PDAC and NSCLC
- Manage program budget with Finance; ensure forecasting and resource alignment
- Coordinate cross-functional readiness for IND amendments, regulatory interactions, and data readouts
Risk Management & Problem Solving
- Proactively identify risks (scientific, operational, regulatory, partnership) and drive contingency planning
- Escalate critical issues to Senior Leadership with clear recommended paths forward
External Collaboration Management
- Support Roche collaboration governance, joint program teams, and data sharing
- Coordinate with CROs and external partners with Clinical Operations
Communication & Reporting
- Prepare/present program updates to Senior Leadership, Board, and external partners
- Ensure alignment between IDE892 plans and corporate priorities/timelines
Requirements
- PhD in relevant life sciences (e.g., biology, pharmacology, biochemistry) required
- 10+ years drug development in pharma/biotech; 5+ years program management
- Experience leading cross-functional oncology teams through Phase 1/2
- Strong oncology scientific fluency
- Proven ability to develop/manage integrated program plans, budgets, and risk frameworks
- Experience managing program-level external collaborations
- Exceptional communication/facilitation; ability to align senior stakeholders
- Experience with RAS-driven cancers (PDAC, NSCLC, CRC) or MTAP/EGFR/KRAS biology
- Familiarity with combination oncology strategy (contribution-of-components)
- Experience supporting registrational programs (BLA/NDA or sNDA)
- Prior lean, clinical-stage biotech experience managing multiple program arms
- PMP certification or equivalent training
Total Rewards / Benefits (as stated)
- Medical/dental/vision coverage (100% company paid for employees; 90% for dependents), 401k, ESPP, wellness programs
- Expected salary range: $255,000–$315,000
Work location
- South San Francisco, CA; onsite four days per week per company policy.
Strategic Program Leadership
- Serve as Project Manager for IDE892, owning overall program strategy with the Clinical Lead and Head of Research
- Integrate scientific, clinical, regulatory, and commercial perspectives into a Development Plan and Target Product Profile (TPP)
- Lead scenario planning, portfolio prioritization, and trade-off analyses for Senior Leadership and the Board
- Serve as key point of contact for the Roche collaboration on IDE892 (Joint Steering Committee prep and cross-company alignment)
- Anticipate strategic inflection points (combination selection, indication prioritization, registrational entry)
Operational Execution
- Own and maintain IDE892 integrated program timeline, critical path, milestone tracking, and risk register
- Lead cross-functional Program Team meetings; drive decisions, document outcomes, and ensure accountability
- Partner with Clinical Operations to oversee study execution across IDE892-001 cohorts, including RAS combination arms and expansion into PDAC and NSCLC
- Manage program budget with Finance; ensure forecasting and resource alignment
- Coordinate cross-functional readiness for IND amendments, regulatory interactions, and data readouts
Risk Management & Problem Solving
- Proactively identify risks (scientific, operational, regulatory, partnership) and drive contingency planning
- Escalate critical issues to Senior Leadership with clear recommended paths forward
External Collaboration Management
- Support Roche collaboration governance, joint program teams, and data sharing
- Coordinate with CROs and external partners with Clinical Operations
Communication & Reporting
- Prepare/present program updates to Senior Leadership, Board, and external partners
- Ensure alignment between IDE892 plans and corporate priorities/timelines
Requirements
- PhD in relevant life sciences (e.g., biology, pharmacology, biochemistry) required
- 10+ years drug development in pharma/biotech; 5+ years program management
- Experience leading cross-functional oncology teams through Phase 1/2
- Strong oncology scientific fluency
- Proven ability to develop/manage integrated program plans, budgets, and risk frameworks
- Experience managing program-level external collaborations
- Exceptional communication/facilitation; ability to align senior stakeholders
- Experience with RAS-driven cancers (PDAC, NSCLC, CRC) or MTAP/EGFR/KRAS biology
- Familiarity with combination oncology strategy (contribution-of-components)
- Experience supporting registrational programs (BLA/NDA or sNDA)
- Prior lean, clinical-stage biotech experience managing multiple program arms
- PMP certification or equivalent training
Total Rewards / Benefits (as stated)
- Medical/dental/vision coverage (100% company paid for employees; 90% for dependents), 401k, ESPP, wellness programs
- Expected salary range: $255,000–$315,000
Work location
- South San Francisco, CA; onsite four days per week per company policy.