Senior Director, Pharmacometrics

Role: Senior Director, Pharmacometrics leading model-informed drug development for targeted oncology therapeutics, including ADCs and radioligands. Responsibilities: develop and implement quantitative strategies across clinical programs; lead PK, PK/PD, exposure-response, and simulation analyses; collaborate with cross-functional teams to integrate pharmacometrics into development plans; author and review regulatory submissions and modeling documentation; manage external vendors; mentor team members; communicate complex modeling results to stakeholders. Requirements: Ph.D. in Pharmacometrics, Pharmacology, or related field with 12+ years (Ph.D.), 15+ years (M.S.), or 18+ years (B.S.) of industry experience; proven leadership in clinical pharmacology and model-based decision-making; expertise in population PK, PK/PD, PBPK, QSP, simulation tools (NONMEM, Monolix, R, etc.); experience supporting global regulatory filings; oncology drug development experience, particularly ADCs, biologics, or targeted radiotherapies. High-Value: Oncology, targeted therapies, ADCs, radioligands, model-informed drug development, regulatory interactions, global clinical programs. WorkSetup: not specified; likely hybrid or onsite given seniority and cross-functional collaboration.