Senior Director, Pharmacokinetics
Merck
August 29, 2026
Remote friendly (South San Francisco, CA)
United States
Clinical Research and Development
Key Responsibilities:
- Provide scientific and portfolio leadership for bioanalytical strategy across discovery programs, ensuring fit-for-purpose assay execution, data quality, compliance, and decision impact across biologics, conjugates, peptides, small molecules, and emerging modalities.
- Drive operational excellence via workflow optimization, capacity planning, automation, digital tools/data systems, and continuous improvement; harmonize approaches across teams/sites/partners; monitor scientific/technology/regulatory trends and champion new methodologies.
- Manage and develop DMPK team representatives, bioanalytical leaders/scientists; set expectations, prioritize work, and support career development.
- Represent PDMB on cross-functional discovery/development teams, integrating bioanalytical, ADME, PK/PD, translational, and regulatory perspectives to guide program decisions and deliver regulatory-ready, nonclinical-to-clinical support.
- Serve as scientific advisor/principal investigator for programs or workstreams.
- Review/author/present scientific and regulatory documents and decision materials.
- Foster innovation, accountability, collaboration, inclusion, safety, quality, and compliance.
Qualifications:
- Master’s (15+ years) or Ph.D. (12+ years) in relevant scientific field with significant bioanalytical/DMPK/drug discovery & development experience.
Required Experience/Skills:
- Demonstrated bioanalysis leadership (assay strategy, method development/validation/qualification, sample analysis, interpretation, reporting).
- Strong understanding of bioanalytical approaches for multiple modalities; cross-functional program experience integrating ADME/PK/PK-PD/translational/toxicology/regulatory.
- Portfolio management and people leadership; excellent written/verbal communication; collaboration/influencing.
Preferred Skills:
- Experience modernizing workflows (automation/digital tools/harmonization/process improvement).
- Translational PK/PD, exposure-response, dose projection, biomarkers, model-informed drug development; experience with complex/emerging modalities; cell-based assays/biophysical/biochemical characterization; scientific visibility.
Benefits (as stated): medical/dental/vision, retirement/401(k), paid holidays, vacation, and compassionate/sick days.
Application Instructions:
- Apply at https://jobs.merck.com/us/en (or Workday Jobs Hub). Application deadline is stated on the posting.
- Provide scientific and portfolio leadership for bioanalytical strategy across discovery programs, ensuring fit-for-purpose assay execution, data quality, compliance, and decision impact across biologics, conjugates, peptides, small molecules, and emerging modalities.
- Drive operational excellence via workflow optimization, capacity planning, automation, digital tools/data systems, and continuous improvement; harmonize approaches across teams/sites/partners; monitor scientific/technology/regulatory trends and champion new methodologies.
- Manage and develop DMPK team representatives, bioanalytical leaders/scientists; set expectations, prioritize work, and support career development.
- Represent PDMB on cross-functional discovery/development teams, integrating bioanalytical, ADME, PK/PD, translational, and regulatory perspectives to guide program decisions and deliver regulatory-ready, nonclinical-to-clinical support.
- Serve as scientific advisor/principal investigator for programs or workstreams.
- Review/author/present scientific and regulatory documents and decision materials.
- Foster innovation, accountability, collaboration, inclusion, safety, quality, and compliance.
Qualifications:
- Master’s (15+ years) or Ph.D. (12+ years) in relevant scientific field with significant bioanalytical/DMPK/drug discovery & development experience.
Required Experience/Skills:
- Demonstrated bioanalysis leadership (assay strategy, method development/validation/qualification, sample analysis, interpretation, reporting).
- Strong understanding of bioanalytical approaches for multiple modalities; cross-functional program experience integrating ADME/PK/PK-PD/translational/toxicology/regulatory.
- Portfolio management and people leadership; excellent written/verbal communication; collaboration/influencing.
Preferred Skills:
- Experience modernizing workflows (automation/digital tools/harmonization/process improvement).
- Translational PK/PD, exposure-response, dose projection, biomarkers, model-informed drug development; experience with complex/emerging modalities; cell-based assays/biophysical/biochemical characterization; scientific visibility.
Benefits (as stated): medical/dental/vision, retirement/401(k), paid holidays, vacation, and compassionate/sick days.
Application Instructions:
- Apply at https://jobs.merck.com/us/en (or Workday Jobs Hub). Application deadline is stated on the posting.