Senior Director, Pharmaceutical Strategy and Development Leader
Crinetics Pharmaceuticals
9 hours ago
Remote friendly (San Diego, CA)
United States
$214,000 - $268,000 USD yearly
Clinical Research and Development
Position: Senior Director, Pharmaceutical Development Team Leader (PDTL)
Position Summary
- Lead and execute comprehensive, compound-specific Technical Operations strategies to meet global project team (GPT) needs.
- Provide leadership to interdisciplinary teams, manage multiple assets through development stages, and collaborate across functions to achieve development and business results.
Essential Job Functions and Responsibilities
- Develop, refine, update, and oversee Technical Operations project plans aligned with strategic objectives; decompose objectives into WBS-level work packages; map internal/cross-functional interdependencies; manage project risks.
- Conduct detailed scenario planning under ambiguity, including scope, cost, timeline, and risk.
- Lead interdisciplinary matrix teams delivering compound-specific integrated Technical Operations strategies.
- Manage multiple assets from candidate nomination through commercial formulation and manufacturing.
- Represent Technical Operations on GPTs; collaborate with Clinical, Commercial, Regulatory, and other functions to integrate plans/activities into GPT goals.
- Communicate and partner with stakeholders to define and execute Technical Operations strategy.
- Identify and escalate key issues/risks and resource allocation needs.
- Critically review Technical Operations regulatory submissions and briefing booklets.
- Promote best practices and lead improvement opportunities.
- Partner with Corporate Development to support Due Diligence evaluations.
Required Qualifications
- MSc or PhD in a relevant technical/scientific discipline.
- 15+ years of CMC experience across development phases, including regulatory submissions (IND, NDA/MAA, IMPD) with a strong success track record.
- Broad understanding of process chemistry, drug substance, drug product development, and analytical development.
- Proven track record in CMC development of clinical stage programs.
- Strong understanding of CMC integration with Non-Clinical and Clinical development, Quality, Regulatory, and Commercial areas.
- Demonstrated project management experience.
- Strategic and tactical project leadership experience.
- Excellent verbal and written communication skills.
- Experience leading empowered, highly collaborative matrix teams.
- Ability to manage ambiguity and understand ROI.
Preferred Qualifications
- Experience in multiple modalities.
Work/Travel Requirements
- Travel up to 30% of the time.
- Biology/chemical laboratory environment experience (if applicable).
Benefits (as stated)
- Discretionary annual target bonus; stock options; ESPP; 401(k) match.
- Medical, dental, vision, and basic life insurance; 20 days PTO; 10 paid holidays; winter company shutdown.
- Salary range: $214,000–$268,000.
Position Summary
- Lead and execute comprehensive, compound-specific Technical Operations strategies to meet global project team (GPT) needs.
- Provide leadership to interdisciplinary teams, manage multiple assets through development stages, and collaborate across functions to achieve development and business results.
Essential Job Functions and Responsibilities
- Develop, refine, update, and oversee Technical Operations project plans aligned with strategic objectives; decompose objectives into WBS-level work packages; map internal/cross-functional interdependencies; manage project risks.
- Conduct detailed scenario planning under ambiguity, including scope, cost, timeline, and risk.
- Lead interdisciplinary matrix teams delivering compound-specific integrated Technical Operations strategies.
- Manage multiple assets from candidate nomination through commercial formulation and manufacturing.
- Represent Technical Operations on GPTs; collaborate with Clinical, Commercial, Regulatory, and other functions to integrate plans/activities into GPT goals.
- Communicate and partner with stakeholders to define and execute Technical Operations strategy.
- Identify and escalate key issues/risks and resource allocation needs.
- Critically review Technical Operations regulatory submissions and briefing booklets.
- Promote best practices and lead improvement opportunities.
- Partner with Corporate Development to support Due Diligence evaluations.
Required Qualifications
- MSc or PhD in a relevant technical/scientific discipline.
- 15+ years of CMC experience across development phases, including regulatory submissions (IND, NDA/MAA, IMPD) with a strong success track record.
- Broad understanding of process chemistry, drug substance, drug product development, and analytical development.
- Proven track record in CMC development of clinical stage programs.
- Strong understanding of CMC integration with Non-Clinical and Clinical development, Quality, Regulatory, and Commercial areas.
- Demonstrated project management experience.
- Strategic and tactical project leadership experience.
- Excellent verbal and written communication skills.
- Experience leading empowered, highly collaborative matrix teams.
- Ability to manage ambiguity and understand ROI.
Preferred Qualifications
- Experience in multiple modalities.
Work/Travel Requirements
- Travel up to 30% of the time.
- Biology/chemical laboratory environment experience (if applicable).
Benefits (as stated)
- Discretionary annual target bonus; stock options; ESPP; 401(k) match.
- Medical, dental, vision, and basic life insurance; 20 days PTO; 10 paid holidays; winter company shutdown.
- Salary range: $214,000–$268,000.