Senior Director, Oncology Pharmacology
Jazz Pharmaceuticals
August 23, 2026
Remote friendly (Palo Alto, CA)
United States
Clinical Research and Development
Brief Description
- Lead scientific team members assigned to oncology assets from discovery through regulatory approval.
- Manage the oncology pharmacology team and serve as lead on one or more programs.
- Establish efficacy in relevant disease models; demonstrate differentiation vs comparators; determine PK/PD/efficacy relationships; characterize mechanisms of action; identify predictive disease models, indications, and biomarkers.
- Drive preclinical discovery and support R&D of Jazz products and drug candidates; design and execute studies addressing clinically relevant priorities.
- Design/execute outsourced or in-house/academic experiments; review/contribute to clinical protocols; review/author technical reports.
- Coauthor regulatory documents (IND to NDA/BLA); communicate research at internal/external forums.
- Cross-functional matrix work with Clinical Development, Bioanalytical, Toxicology, Clinical Pharmacology, Biomarkers Regulatory Affairs, and Project Management.
- Collaborate with/represent ORP on nonclinical studies in hematologic malignancies and solid tumors.
Essential Functions
- Design/execute studies to elucidate efficacy, tolerability, mechanism of action, and biomarkers across multiple modalities (small molecules, biologics, ADCs, bi-specifics, cell therapies, emerging platforms).
- Critically evaluate biochemical and cellular assays; communicate across matrixed teams.
- Lead program strategy, analyze data, and present to nonclinical/governance teams.
- Partner with CROs/academia; manage timelines/budgets; mentor junior scientists.
Required Knowledge, Skills, and Abilities
- Oncology drug development expertise (hit-to-lead through IND enabling), including Immuno-Oncology models/endpoints.
- Experience across multiple modalities (small molecules, biologics, ADCs, bi-specifics, T cell engagers, cell/gene therapies, RNA therapeutics).
- Strong understanding of Nonclinical Pharmacology, Toxicology, DMPK, and Clinical Pharmacology integration.
- Ability to integrate preclinical/clinical datasets; biomarker analysis (e.g., GraphPad Prism).
- Direct people management; author nonclinical IND/NDA/BLA/MAA components and documents (briefing packages, DSURs, IBs, fast track).
- Strong project management; leadership in fast-paced matrix environments.
Education
- Ph.D. in biology/biochemistry/immunology/pharmacology (or related), with substantial oncology and immuno-oncology experience.
Benefits (US based candidates only)
- Discretionary annual cash bonus/incentive (role-dependent); discretionary equity grants.
- Medical, dental, vision, 401k, flexible paid vacation.
Application instructions
- If a current Jazz employee: apply via the Internal Career site.
- Lead scientific team members assigned to oncology assets from discovery through regulatory approval.
- Manage the oncology pharmacology team and serve as lead on one or more programs.
- Establish efficacy in relevant disease models; demonstrate differentiation vs comparators; determine PK/PD/efficacy relationships; characterize mechanisms of action; identify predictive disease models, indications, and biomarkers.
- Drive preclinical discovery and support R&D of Jazz products and drug candidates; design and execute studies addressing clinically relevant priorities.
- Design/execute outsourced or in-house/academic experiments; review/contribute to clinical protocols; review/author technical reports.
- Coauthor regulatory documents (IND to NDA/BLA); communicate research at internal/external forums.
- Cross-functional matrix work with Clinical Development, Bioanalytical, Toxicology, Clinical Pharmacology, Biomarkers Regulatory Affairs, and Project Management.
- Collaborate with/represent ORP on nonclinical studies in hematologic malignancies and solid tumors.
Essential Functions
- Design/execute studies to elucidate efficacy, tolerability, mechanism of action, and biomarkers across multiple modalities (small molecules, biologics, ADCs, bi-specifics, cell therapies, emerging platforms).
- Critically evaluate biochemical and cellular assays; communicate across matrixed teams.
- Lead program strategy, analyze data, and present to nonclinical/governance teams.
- Partner with CROs/academia; manage timelines/budgets; mentor junior scientists.
Required Knowledge, Skills, and Abilities
- Oncology drug development expertise (hit-to-lead through IND enabling), including Immuno-Oncology models/endpoints.
- Experience across multiple modalities (small molecules, biologics, ADCs, bi-specifics, T cell engagers, cell/gene therapies, RNA therapeutics).
- Strong understanding of Nonclinical Pharmacology, Toxicology, DMPK, and Clinical Pharmacology integration.
- Ability to integrate preclinical/clinical datasets; biomarker analysis (e.g., GraphPad Prism).
- Direct people management; author nonclinical IND/NDA/BLA/MAA components and documents (briefing packages, DSURs, IBs, fast track).
- Strong project management; leadership in fast-paced matrix environments.
Education
- Ph.D. in biology/biochemistry/immunology/pharmacology (or related), with substantial oncology and immuno-oncology experience.
Benefits (US based candidates only)
- Discretionary annual cash bonus/incentive (role-dependent); discretionary equity grants.
- Medical, dental, vision, 401k, flexible paid vacation.
Application instructions
- If a current Jazz employee: apply via the Internal Career site.