Senior Director - (Medical/M.D.) - ExploR&D Translational Medicine
Eli Lilly and Company
August 13, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
Purpose of the Role
- Senior/Executive Director, ExploR&D Translational Medicine: Own overarching medical strategy and medical oversight for multiple assets across therapeutic areas/modalities; lead early phase clinical development with external partners and internal experts.
Core Job Tasks & Responsibilities
- Accountable for medical/safety leadership for all development phases (candidate selection to proof-of-concept).
- Build and execute clinical development plans; enable risk/decision-making on asset safety/efficacy.
- Partner with program leadership/CRC to develop and execute development plans.
- For FIH assets: work with toxicology/PK on starting doses, dose ranges, and interpreting human PK/PD for escalation and PoC dosing.
- Author/review/approve key documents (protocols, risk profiles, informed consent, clinical study reports, disclosures) and key Investigator Brochure safety sections.
- Provide regulatory support (IND/CTA/IMPD/IB/DSURs; responses to questions).
- Provide medical leadership for early development execution (study design, safety plans, CRO/CRO interactions, start-up, data monitoring, health authority interactions, analyses, reports).
- Lead dose-escalation meetings and trial-level safety reviews; serve as medical monitor; manage/serve as sponsor physician for SAEs; oversee outsourced functions.
- Ensure GCP, compliance, and appropriate risk management/collaborations; support publications/data dissemination.
Basic Qualifications (Required)
- MD or DO; board eligible/certified (or equivalent post-medical school training per hiring country); non-US training must meet LCME requirements.
- At least 3 years of direct pharmaceutical industry experience.
Additional Preferences
- 5–7+ years industry (or equivalent investigator experience) with extensive Phase 1/2a protocol authoring/execution across therapeutic areas.
- Deep GCP and clinical trial medical safety experience (investigator or sponsor side).
- Strong clinical pharmacology/translational biology (MS/PhD a plus).
- Strong computer skills (Word, Excel, PowerPoint, Teams, SharePoint).
Benefits (as stated)
- Eligibility for company bonus; 401(k), pension; vacation; medical/dental/vision/prescription; flexible benefits; life insurance/death benefits; certain time off/leave; well-being benefits (EAP, fitness, clubs).
Other Information
- Hybrid role in Boston, MA or Indianapolis, IN (remote for exceptional candidates); ~25% travel.
- Senior/Executive Director, ExploR&D Translational Medicine: Own overarching medical strategy and medical oversight for multiple assets across therapeutic areas/modalities; lead early phase clinical development with external partners and internal experts.
Core Job Tasks & Responsibilities
- Accountable for medical/safety leadership for all development phases (candidate selection to proof-of-concept).
- Build and execute clinical development plans; enable risk/decision-making on asset safety/efficacy.
- Partner with program leadership/CRC to develop and execute development plans.
- For FIH assets: work with toxicology/PK on starting doses, dose ranges, and interpreting human PK/PD for escalation and PoC dosing.
- Author/review/approve key documents (protocols, risk profiles, informed consent, clinical study reports, disclosures) and key Investigator Brochure safety sections.
- Provide regulatory support (IND/CTA/IMPD/IB/DSURs; responses to questions).
- Provide medical leadership for early development execution (study design, safety plans, CRO/CRO interactions, start-up, data monitoring, health authority interactions, analyses, reports).
- Lead dose-escalation meetings and trial-level safety reviews; serve as medical monitor; manage/serve as sponsor physician for SAEs; oversee outsourced functions.
- Ensure GCP, compliance, and appropriate risk management/collaborations; support publications/data dissemination.
Basic Qualifications (Required)
- MD or DO; board eligible/certified (or equivalent post-medical school training per hiring country); non-US training must meet LCME requirements.
- At least 3 years of direct pharmaceutical industry experience.
Additional Preferences
- 5–7+ years industry (or equivalent investigator experience) with extensive Phase 1/2a protocol authoring/execution across therapeutic areas.
- Deep GCP and clinical trial medical safety experience (investigator or sponsor side).
- Strong clinical pharmacology/translational biology (MS/PhD a plus).
- Strong computer skills (Word, Excel, PowerPoint, Teams, SharePoint).
Benefits (as stated)
- Eligibility for company bonus; 401(k), pension; vacation; medical/dental/vision/prescription; flexible benefits; life insurance/death benefits; certain time off/leave; well-being benefits (EAP, fitness, clubs).
Other Information
- Hybrid role in Boston, MA or Indianapolis, IN (remote for exceptional candidates); ~25% travel.