Senior Director, Material Science
Vertex Pharmaceuticals
4 days ago
On-site
Boston, MA
Operations
General Summary:
Vertex is seeking a Material Science Senior Director to lead the Materials Development Group in Boston, MA, supporting drug development programs through expertise in relationships between materials properties, pharmaceutical processing conditions, and final product performance/quality.
Key Duties And Responsibilities:
- Lead a team responsible to:
- Design experiments for solid form discovery/development (stable form identification, polymorphism, salts, co-crystals, amorphous material, etc.) for pharmaceutical solid-state materials.
- Design, validate, and implement advanced characterization techniques and predictive models connecting material properties, processing conditions, and final product performance to streamline process development and formulation design.
- Leverage physiochemical and biopharmaceutical knowledge to influence in vitro and/or in vivo studies for discovery and formulation development.
- Decipher pharmacokinetic data and nominate the most appropriate API polymorph across development phases.
- Drive project activities and scientific strategies (including at external CROs); potentially lead projects across pharmaceutical sciences.
- Drive innovation and explore new scientific projects/business initiatives.
- Mentor junior-level scientists; develop team members.
- Manage multiple assets in a fast-paced environment using limited/evolving data.
- Build internal/external networks via meetings and publishing.
- Influence strategic direction of the Materials Development Group and Engineering and Materials Science department.
- Collaborate with an interdisciplinary team.
Knowledge And Skills:
- Experience leading pharmaceutical materials discovery teams.
- Advanced knowledge of solid form discovery/development/characterization (including computational modeling) from GLP Tox to commercial.
- Accountability for polymorph selection; pharmacokinetic principles.
- Process development and problem-solving in matrix environments.
- Strong communication and stakeholder influence.
Education And Experience:
- BS (+20 years), MS (+15 years), or PhD (+11 years) in Materials Science/Chemistry or related field, with relevant pharmaceutical materials development experience.
- 5 years managing a team.
Vertex is seeking a Material Science Senior Director to lead the Materials Development Group in Boston, MA, supporting drug development programs through expertise in relationships between materials properties, pharmaceutical processing conditions, and final product performance/quality.
Key Duties And Responsibilities:
- Lead a team responsible to:
- Design experiments for solid form discovery/development (stable form identification, polymorphism, salts, co-crystals, amorphous material, etc.) for pharmaceutical solid-state materials.
- Design, validate, and implement advanced characterization techniques and predictive models connecting material properties, processing conditions, and final product performance to streamline process development and formulation design.
- Leverage physiochemical and biopharmaceutical knowledge to influence in vitro and/or in vivo studies for discovery and formulation development.
- Decipher pharmacokinetic data and nominate the most appropriate API polymorph across development phases.
- Drive project activities and scientific strategies (including at external CROs); potentially lead projects across pharmaceutical sciences.
- Drive innovation and explore new scientific projects/business initiatives.
- Mentor junior-level scientists; develop team members.
- Manage multiple assets in a fast-paced environment using limited/evolving data.
- Build internal/external networks via meetings and publishing.
- Influence strategic direction of the Materials Development Group and Engineering and Materials Science department.
- Collaborate with an interdisciplinary team.
Knowledge And Skills:
- Experience leading pharmaceutical materials discovery teams.
- Advanced knowledge of solid form discovery/development/characterization (including computational modeling) from GLP Tox to commercial.
- Accountability for polymorph selection; pharmacokinetic principles.
- Process development and problem-solving in matrix environments.
- Strong communication and stakeholder influence.
Education And Experience:
- BS (+20 years), MS (+15 years), or PhD (+11 years) in Materials Science/Chemistry or related field, with relevant pharmaceutical materials development experience.
- 5 years managing a team.