SENIOR DIRECTOR, HEAD PRECISION MEDICINE

Day One Biopharmaceuticals is an emerging, mission-driven, drug development company intentionally designed to identify, clinically evaluate, and successfully commercialize novel treatments for pediatric oncology patients, and ultimately to expand those benefits to patients of all ages. For more information, please visit our website at http://www.dayonebio.com.

Position Summary

Day One Biopharmaceuticals is seeking a creative, intelligent, deeply committed, high-integrity, scientific leader to develop and maintain precision medicine vision and strategy and provide expertise in clinical diagnostics across our portfolio of targeted therapeutics for children and adults with cancer. In conjunction with senior leaders in Clinical Development, Translational Research, and Regulatory Sciences, and supported by a deeply experienced cross-functional team of experts in pediatric drug development, you will be accountable for ensuring the consistent application of precision medicine across all stages of clinical development. This individual will be a key member of the Clinical Development Team within our Research and Development organization and will report to our Vice President, Clinical Development. As a Leader at Day One, your responsibilities will also include contributing to corporate strategy, building a sustainable culture, recruiting, and enabling company growth. This position has the potential to be fully remote. Occasional travel will be required for in person meetings.

Who You Are

What matters most to you is helping address unmet need for underserved cancer patient populations. You are therefore patient-focused, driven, and have a track record of finding gaps, turning them into opportunities, and delivering solutions to move forward the mission of Day One. Others frequently call you for your help when considering the impact of molecular diagnostics and precision medicine on their functions. You consume data about oncology drug development and clinical diagnostics constantly because you love it and are always on the frontier of emerging information so you can learn and adapt fast. In the face of emerging data, you are open to re-evaluating older processes and assumptions. Your best days are when you find a new insight that changes your mind and provides a promising opportunity to help patients in need. You understand the high degree of uncertainty in our field and are comfortable both navigating the unknown and bringing others along with you.

You have a healthy degree of skepticism and a desire to dig into the data yourself. You are comfortable making recommendations with imperfect information. Not solely dependent on process, your instinct is to just dive in, but at the same time you recognize we can only go far together. You are a leader who others love to follow because of your integrity, authenticity, candor, desire to pursue truth, and high expectations. Leading by example is the only form of leadership you know. You have been a part of, and led, high performing teams of all sizes.

Essential Duties And Responsibilities

• The Head of Precision Medicine is accountable for precision medicine vision and strategy.
• Provide strong supporting cross-functional partnerships with Leadership of Clinical Development, Translational Research, Regulatory Sciences, Clinical Pharmacology, Commercial and other Day One functions.
• Provide technical and clinical expertise in molecular diagnostics across diverse stakeholders comprising leadership in Research and Development, Commercial, Regulatory Sciences, Medical Affairs, and Patient Advocacy, including but not limited to, training, education, and representation in precision medicine-related events with patient advocacy organizations.
• Accountable for developing and maintaining strategies to support indication selection and patient eligibility screening execution across clinical programs, leveraging your extensive experience, via global and subject matter expertise, in diagnostic testing development and report interpretation.
• Work closely with Business Development and internal teams to support candidate asset acquisition assessments through precision medicine considerations.
• Accountable to create and support comprehensive clinical biomarkers and diagnostic strategies, including companion diagnostics, globally, across clinical programs through the identification of predictive markers and clinical validation to strongly influence clinical development strategy and interpretation of data from clinical studies through prospective analysis of predictive hypotheses.
• Accountable for all scientific, technical, clinical, financial, regulatory, intellectual property, commercial and partnering aspects needed to implement clinical biomarker diagnostic strategy across the portfolio and future assets (to include informing asset assessment strategies).
• Accountable to Product Teams and Senior/Executive Leadership for Precision Medicine ensuring that the clinical biomarker diagnostic development reflects world-class practices in the field and contributes to an increased probability of successful approval, drug launch, clinical utility, reimbursement & ROI.
• Accountable for optimal resourcing, budget management, governance interactions, engagement with internal and external experts regarding Precision Medicine.
• Author and develop precision medicine relevant publications and communications.
• Represent Precision Medicine function at advisory boards and health authority interactions to advance communications and objectives for each program.
• Help Day One remain a leader in oncology drug development.
• Provide mentorship and personal development of team members by engaging, inspiring, and successfully communicating with reports and employees of any level in the organization.
• Understand and embrace one of our highest values: that the most precious asset is our team.
• Proactively contribute to company-building and process evolution as we grow.

Qualifications

• PhD; MD/PhD or Master’s with industry experience in molecular biology, chemistry, pharmacology, biology, biochemistry, or a related discipline.
• A minimum of 15 years of experience in commercial biomarker and diagnostic development and/or oncology drug discovery/development setting within the biopharmaceutical industry (biotech or pharma or CRO/Central Labs).
• Comprehensive experience in -omics technology (genomics, proteomics, metabolomics) in precision medicine, molecular diagnostics, immuno-based diagnostics, LC/MS, cancer biology and drug development from concept through regulatory approval and commercialization is required.
• Development and regulatory approval and commercial launch of a companion diagnostic.
• Pediatric oncology and/or rare disease experience, expertise in the interpretation of clinical molecular diagnostic testing reports, and understanding of clinical biomarkers and Companion Diagnostics development strategy and execution is strongly desired.
• Experience in global business development as part of cross-functional corporate strategy in Precision Medicine is required.
• Unwavering integrity and trustworthiness, embodying Day One’s core values.
• Eloquent and passionate when talking about science and the potential to help patients.
• Keen scientific acumen and intellectual curiosity, good judgement, and the highest scientific integrity.
• Curious, creative with an ability to think outside of traditional drug development and corporate models.
• A team player and a mentor – someone who cares for their colleagues as people as well as contributors and collaborators, while delivering results.
• Inspires the confidence of others, and inspires others to fulfill their potential.
• The ability to elicit and synthesize information from a range of individuals and sources rapidly and clearly communicate findings across the organization.
• Start-up/small biotech (A sense of humor, a keen wit, a strong sense drive, and a chronically positive attitude are always desired; Day One embraces diversity on all parameters).

INTERVIEW INTEGRITY

At Day One, we expect each candidate to engage authentically, representing their true qualifications and experiences. As part of our screening process, we will conduct several interviews and background verification. This ensures candidates have the skills they claim and align with our values. We are excited to learn more about you and to create a genuine experience for everyone.

Compensation And Benefits

The salary range for this position is $270,000 - $290,000. Day One considers a range of factors when determining base compensation. These considerations mean actual compensation will vary.

Please visit https://www.dayonebio.com/benefits to see our competitive benefits.

DISCLAIMER

Day One Biopharmaceuticals is committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law.

Employment is conditioned upon full vaccination from the COVID-19 virus, including submission of documented proof thereof, as of the start date. Day One Biopharmaceuticals will comply with applicable law regarding the reasonable accommodation of individuals who are not vaccinated because of a disability and/or a sincerely held religious belief.

We are unable to sponsor or take over sponsorship of any applicant work visas at this time.

Recruitment & Staffing Agencies

Day One Biopharmaceuticals does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Day One Biopharmaceuticals or its employees is strictly prohibited unless contacted directly by Day One Biopharmaceutical’s internal HR team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Day One Biopharmaceuticals, and Day One Biopharmaceuticals will not owe any referral or other fees with respect thereto.