Senior Director, Head of PV Science

Role: Senior Director of PV Science and Aggregate Reports, leading pharmacovigilance safety and aggregate report functions for Alnylam's RNAi therapeutics pipeline. Responsibilities: manage PV scientists, oversee safety profiles, develop risk management systems, ensure timely creation and submission of aggregate safety reports (DSURs, PSURs), and lead cross-functional collaborations for safety and regulatory compliance. Requirements: Master’s or doctorate in a healthcare or scientific discipline; 12+ years in pharma, including 8+ in drug safety/PV, with 5+ years in team leadership; deep knowledge of global PV regulations, safety operations, and database tools (e.g., Argus, Signaling). HighValue: RNAi therapeutics, rare disease focus, late-stage development, regulatory reporting, global safety oversight, experience with safety literature monitoring, and risk management planning. WorkSetup: hybrid (2 days/week onsite) in Cambridge or Philadelphia.