Senior Director, Evidence Generation
Xeris Pharmaceuticals, Inc.
July 02, 2026
Remote friendly (Chicago, IL)
United States
Market Access
Responsibilities:
- Develop and execute integrated HEOR and evidence generation strategies across the product lifecycle (portfolio planning and lifecycle management).
- Define the vision, structure, and capabilities of the Evidence Generation team (future state) with Medical Affairs leadership.
- Identify evidence gaps; prioritize studies to support payer/provider/institution/patient decision-making.
- Provide HEOR input to clinical development (endpoint selection and evidence planning).
- Lead economic modeling: budget impact analyses, cost-effectiveness studies, and value dossiers.
- Oversee comparative effectiveness and burden-of-illness evidence generation.
- Guide development of patient-reported outcomes (PRO) and health-related quality-of-life research.
- Ensure methodological rigor for all real-world evidence (RWE) initiatives; align projects with medical and brand strategy.
- Evaluate/acquire novel data sources; oversee retrospective database analyses, pragmatic trials, and outcomes research with medical/scientific leads and external experts.
- Build relationships with external researchers and evidence-generation partners.
- Manage strategic/internal-external communications for successful completion and data disclosure; provide executive-level engagement.
- Oversee external vendors/partnerships; collaborate with Publications/Medical Communications to publish research.
Qualifications:
- PhD/DrPH/ScD/PharmD/MD or equivalent in Health Economics, Outcomes Research, Epidemiology, Public Health, Health Services Research, Biostatistics, Pharmacy, Medicine, or related field.
- Demonstrated expertise in health economics/pharmacoepidemiology/biostatistics/RWE.
- 12+ years in HEOR/outcomes research/epidemiology/market access/evidence generation (pharma/biotech/consulting/healthcare).
- Experience supporting payer engagement and reimbursement strategy.
- Track record of peer-reviewed publications and major congress presentations.
Technical competencies:
- Health economics modeling and value assessment; RWE strategy; comparative effectiveness; PRO/QoL; epidemiology/observational design; market access/reimbursement; HTA; evidence synthesis/SRLs; data analytics/healthcare databases; scientific communications.
Working conditions:
- Periodic evening/weekend work; periodic overnight travel; vehicle and air travel possible; hybrid in Chicago requiring at least 3 days/week on-site.
Compensation:
- Anticipated base salary range: $252,000–$337,000.
Application instructions:
- If you need a reasonable accommodation during the application process, email recruiting@xerispharma.com with the job requisition number.
- Develop and execute integrated HEOR and evidence generation strategies across the product lifecycle (portfolio planning and lifecycle management).
- Define the vision, structure, and capabilities of the Evidence Generation team (future state) with Medical Affairs leadership.
- Identify evidence gaps; prioritize studies to support payer/provider/institution/patient decision-making.
- Provide HEOR input to clinical development (endpoint selection and evidence planning).
- Lead economic modeling: budget impact analyses, cost-effectiveness studies, and value dossiers.
- Oversee comparative effectiveness and burden-of-illness evidence generation.
- Guide development of patient-reported outcomes (PRO) and health-related quality-of-life research.
- Ensure methodological rigor for all real-world evidence (RWE) initiatives; align projects with medical and brand strategy.
- Evaluate/acquire novel data sources; oversee retrospective database analyses, pragmatic trials, and outcomes research with medical/scientific leads and external experts.
- Build relationships with external researchers and evidence-generation partners.
- Manage strategic/internal-external communications for successful completion and data disclosure; provide executive-level engagement.
- Oversee external vendors/partnerships; collaborate with Publications/Medical Communications to publish research.
Qualifications:
- PhD/DrPH/ScD/PharmD/MD or equivalent in Health Economics, Outcomes Research, Epidemiology, Public Health, Health Services Research, Biostatistics, Pharmacy, Medicine, or related field.
- Demonstrated expertise in health economics/pharmacoepidemiology/biostatistics/RWE.
- 12+ years in HEOR/outcomes research/epidemiology/market access/evidence generation (pharma/biotech/consulting/healthcare).
- Experience supporting payer engagement and reimbursement strategy.
- Track record of peer-reviewed publications and major congress presentations.
Technical competencies:
- Health economics modeling and value assessment; RWE strategy; comparative effectiveness; PRO/QoL; epidemiology/observational design; market access/reimbursement; HTA; evidence synthesis/SRLs; data analytics/healthcare databases; scientific communications.
Working conditions:
- Periodic evening/weekend work; periodic overnight travel; vehicle and air travel possible; hybrid in Chicago requiring at least 3 days/week on-site.
Compensation:
- Anticipated base salary range: $252,000–$337,000.
Application instructions:
- If you need a reasonable accommodation during the application process, email recruiting@xerispharma.com with the job requisition number.