Senior Director, Discovery Sciences & Technologies

Role: Senior Director, Discovery Sciences & Technologies at Gilead, providing strategic leadership in assay development, high-throughput screening, and advanced drug discovery technologies across multiple modalities including small molecules, biologics, and heterobifunctional compounds. Objectives: enable target validation, hit identification, lead optimization, and progression to development candidates. Responsibilities: lead and mentor a team designing biochemical, biophysical, and cellular assays; establish assay and screening strategies; drive adoption of next-generation technologies; evaluate external innovations; provide scientific guidance to project teams; manage resources across programs; foster a collaborative, innovative culture. Requirements: PhD in biochemistry, enzymology, biophysics, or related field; 15+ years in industrial drug discovery; deep expertise in protein–ligand interactions, biophysical and cellular assay development; success in advancing programs from HTS to candidate nomination; experience with mass spectrometry, covalent inhibitors, and degrader modalities preferred; proven leadership ability. HighValue: leadership in assay and screening technologies, biologics and small molecules, early discovery to candidate selection, cross-functional collaboration, matrixed research environment, strategic evaluation of external innovation, and talent development. Location: not specified; role involves senior leadership within Gilead’s research organization.