Senior Director, Development Pharmacology & Toxicology
Intellia Therapeutics, Inc.
June 25, 2026
Remote friendly (Cambridge, MA)
United States
Clinical Research and Development
How You Will Achieve More
The Senior Director of Development Pharmacology & Toxicology provides strategic leadership in establishing and executing pharmacology and toxicology strategies across multiple therapeutic platforms (nucleic acid, lipid nanoparticle, cell therapy, small and large molecule). Oversees cross-functional teams to ensure regulatory success across development programs.
Responsibilities
- Establish and direct platform-wide testing strategies across therapeutic modalities, anticipating guidance from FDA, EMA, ICH, and other agencies.
- Lead development of GLP compliance frameworks; integrate GMP considerations into nonclinical testing strategies.
- Guide design and oversee execution of critical nonclinical studies, including pivotal GLP toxicology studies for clinical advancement.
- Engage externally to shape regulatory thinking around novel therapeutic modalities.
- Direct preparation and review of regulatory submission packages for INDs, CTAs, BLAs, and NDAs; determine nonclinical content strategy.
- Lead cross-functional initiatives across research, clinical development, manufacturing, regulatory affairs, and QA.
- Define integration between Discovery PharmTox and Development PharmTox to enable cohesive pipeline progression.
- Establish departmental priorities and resource allocation in partnership with Preclinical Operations.
- Represent the company in critical regulatory agency interactions.
- Direct due diligence for partnerships, in-licensing, or acquisitions.
- Contribute to R&D leadership; assume broader VP responsibilities in their absence or by delegation.
Supervisory Responsibilities
- Recruit, interview, hire, train; oversee daily workflow; foster collaboration; conduct performance evaluations; handle discipline/termination.
About You (Qualifications/Skills)
- Comprehensive knowledge of IACUC, GLP, laboratory safety, and data integrity.
- Proficiency: Microsoft Word, Excel, PowerPoint, MS Project.
- Experience managing scientific projects in a matrixed environment.
- Experience managing rodent and large animal (e.g., non-human primate) studies.
- BS/MS/PhD in pharmacology, toxicology, or related field.
- Required experience: 15+ years (BS), 12+ years (MS), or 10+ years (PhD); 7+ years supervisory experience.
Application Instructions
- Applications are accepted on a rolling basis until the position is filled.
The Senior Director of Development Pharmacology & Toxicology provides strategic leadership in establishing and executing pharmacology and toxicology strategies across multiple therapeutic platforms (nucleic acid, lipid nanoparticle, cell therapy, small and large molecule). Oversees cross-functional teams to ensure regulatory success across development programs.
Responsibilities
- Establish and direct platform-wide testing strategies across therapeutic modalities, anticipating guidance from FDA, EMA, ICH, and other agencies.
- Lead development of GLP compliance frameworks; integrate GMP considerations into nonclinical testing strategies.
- Guide design and oversee execution of critical nonclinical studies, including pivotal GLP toxicology studies for clinical advancement.
- Engage externally to shape regulatory thinking around novel therapeutic modalities.
- Direct preparation and review of regulatory submission packages for INDs, CTAs, BLAs, and NDAs; determine nonclinical content strategy.
- Lead cross-functional initiatives across research, clinical development, manufacturing, regulatory affairs, and QA.
- Define integration between Discovery PharmTox and Development PharmTox to enable cohesive pipeline progression.
- Establish departmental priorities and resource allocation in partnership with Preclinical Operations.
- Represent the company in critical regulatory agency interactions.
- Direct due diligence for partnerships, in-licensing, or acquisitions.
- Contribute to R&D leadership; assume broader VP responsibilities in their absence or by delegation.
Supervisory Responsibilities
- Recruit, interview, hire, train; oversee daily workflow; foster collaboration; conduct performance evaluations; handle discipline/termination.
About You (Qualifications/Skills)
- Comprehensive knowledge of IACUC, GLP, laboratory safety, and data integrity.
- Proficiency: Microsoft Word, Excel, PowerPoint, MS Project.
- Experience managing scientific projects in a matrixed environment.
- Experience managing rodent and large animal (e.g., non-human primate) studies.
- BS/MS/PhD in pharmacology, toxicology, or related field.
- Required experience: 15+ years (BS), 12+ years (MS), or 10+ years (PhD); 7+ years supervisory experience.
Application Instructions
- Applications are accepted on a rolling basis until the position is filled.