Senior Director, Development DMPK

Company Name: Rapport Therapeutics

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).

Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder.

The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!

Your Impact

It takes skill and a bit of luck to optimize and arrive at a Development Candidate (DC) and then it takes multi-dimensional experience (e.g. interface with toxicology, clinical development & regulatory affairs) to shepherd a DC towards an IND & NDA. Fully characterizing the disposition profile, metabolism & transporter interactions in humans and therefore the potential for drug-drug interactions are key to navigating the path from IND to NDA.

You will play a key role in supporting drug development programs by providing scientific and strategic leadership in DMPK, working side-by-side with other functions and the project team to steer as well as expedite drug development.

Your Day-to-day

• Design, oversee, and interpret in vitro and in vivo ADME/DMPK studies to support development of pipeline compounds all the way to NDA/submissions across different geographies.
• Collaborate closely with toxicology, clinical pharmacology, clinical development & regulatory affairs to guide small molecule drug development decisions.
• Author DMPK sections of regulatory documents (e.g., IB, CTA, briefing books for milestone meetings with regulatory agencies, NDA).
• Select and manage CROs to ensure timely and high-quality delivery of DMPK data.
• Stay current with emerging DMPK technologies, regulatory guidance, and scientific literature to inform best practices.

Must-Haves

• Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Chemistry, Biology, or a related discipline, with 12+ years of relevant industry experience; or M.S. with 15+ years of experience.
• Strong understanding of small molecule ADME, PK/PD, and metabolism, with a proven track record of supporting drug development.
• Experience with preclinical DMPK study design, data analysis, and regulatory documentation.
• Proficiency with PK modeling software (e.g., Phoenix WinNonlin, GastroPlus, Simcyp) is desirable.
• Excellent communication and presentation skills, with the ability to work effectively in cross-functional teams.
• Self-starter with a proactive attitude and the ability to thrive in a fast-paced, evolving biotech environment.

What Makes Rapport Special

• Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start.
• We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
• Your perspective matters. Stick your neck out, share your ideas – we work as a team.
• We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with.
• Leadership that CARES – about you, your growth + development.
• We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together.
• Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
• You get to be YOU! Show up as you are and make every day count.

Your Compensation

We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for this role to be $265,000 to $285,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company.

Hybrid Work Environment

We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office on Tuesday and Wednesday. In January 2026, this will shift to three days a week to create more opportunities for innovation, collaboration, and connection.

Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Note to Employment Agencies:

Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

CCPA disclosure notice can be found here.