Senior Director, CVRM Genomics Therapeutic Area Lead

Role Summary

Senior Director, CVRM Genomics Therapeutic Area Lead. Lead the CVRM Genomic strategy within CGR, shaping how human genetic and multi-omic evidence informs AstraZeneca’s strategy and pipeline in cardiovascular, renal, and metabolic diseases. Drive target selection, trial design, patient stratification, and biomarker strategy to improve patient outcomes, collaborating across a 60+ partner network and reporting to the VP, CGR Head.

Responsibilities

• Define and lead the CVRM Genomic strategy for CGR, ensuring alignment to unmet patient needs and therapeutic area priorities.
• Bring clinical reasoning and genetic insight to identify disease mechanisms, prioritize targets, and develop biomarker and patient identification strategies.
• Integrate genomic, multi-omic, clinical, biomarker, and real-world evidence to evaluate disease heterogeneity and causal pathways, support mechanism-based development, and inform lifecycle management.
• Collaborate with CVRM TA leadership to apply population genomic insight for patient selection and disease subtyping, and identify biomarkers for stratification to enhance trial interpretability and success.
• Lead scientific collaboration across AstraZeneca and the global research community to prioritize high-value partnerships and investments.
• Mentor and inspire cross-functional teams toward shared goals.

Qualifications

• MD (or international equivalent) and/or relevant PhD with deep CVRM disease biology understanding.
• 3+ years of experience in clinical research and/or drug development in pharmaceutical or academic environments.
• Demonstrated ability to apply human genetics or multi-omics to inform disease mechanisms, patient stratification, therapeutic hypotheses, or clinical trial strategy.
• Experience in genetic epidemiology and/or rare variant interpretation, including evaluating pathogenicity, penetrance, and clinical relevance.
• Proven track record leading complex, cross-functional scientific or clinical research across matrixed teams and external partners.
• Collaborative, patient-centered leader who thrives cross-disciplinarily to solve translational challenges.
• Experience contributing to clinical trial design, patient enrichment strategies, or biomarker-driven study planning.
• Excellent communicator able to convey clinical reasoning and genomic insights to diverse audiences.
• Ability to influence portfolio and investment decisions through scientific and clinical reasoning.
• Experience mentoring and developing scientific talent.

Desirable Criteria

• Recognized scientific contributions (publications, conference presentations, guidelines).
• Experience leveraging human genomics to inform clinical development, biomarker strategy, or real-world evidence studies.
• Familiarity with regulatory, ethical, or privacy considerations for genomic research.
• Clinical experience.