Senior Director, Clinical Scientist
Madrigal Pharmaceuticals
September 02, 2026
Full-time
Remote friendly (Conshohocken, PA)
Worldwide
Clinical Research and Development
Role: Senior Director, Clinical Scientist, leading the scientific strategy and trial design for Madrigal's MASH-focused clinical programs. Responsibilities: contribute to protocol development, author/review key clinical documents, support trial execution, collaborate with cross-functional teams (clinical operations, data management, biostats, medical writing), review data and assist regulatory submissions, and stay current on MASH/NASH therapeutic trends. Requirements: PhD, MD, PharmD, or equivalent with 10+ years in clinical development, ideally in liver/metabolic diseases, with strong knowledge of ICH/GCP regulations. Preferred: experience supporting regulatory interactions, working in biotech, familiarity with liver disease endpoints. The role demands scientific rigor, leadership in study design, and cross-functional collaboration. High-value specifics include focus on MASH/NASH, phases up to (and including) Phase 3, and expertise in metabolic and liver disease development. Work setup details are not specified; collaboration is primarily internal and external stakeholder engagement.