Senior Director, Clinical Portfolio Technology
Alnylam Pharmaceuticals
Full-time
Remote friendly (Cambridge, MA)
United States
$226,800 - $306,800 USD yearly
IT
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Role Summary
Senior Director, Clinical Portfolio Technology – strategic technology leader driving strategy, delivery, and governance of platforms supporting Clinical Delivery, Portfolio Management, and DSSE. Translates business strategy into validated, compliant, and AI-enabled capabilities to accelerate study execution, optimize portfolio analytics, and enable advanced data science and statistical insights.
Responsibilities
- Strategic Partnership & Engagement: Serve as a thought partner to Clinical Ops, Study Management, Portfolio/PPM leadership, and DSSE; build collaborative relationships to anticipate needs, align technology roadmaps, and drive shared outcomes.
- Clinical Delivery & Portfolio Technology Leadership: Own product and platform roadmaps for clinical trial execution, study management, and portfolio analytics; define capability priorities and success metrics; govern scope, risk, dependencies, and budgets; drive value realization and cost optimization.
- DSSE Enablement: Partner with DSSE to enable analytics, statistical computing, and real-world evidence generation; integrate data standards and support data stewardship, automation, and AI-enabled insights; champion centralized dashboards and data visualization.
- Portfolio Analytics & Decision Support: Provide data-driven insights, scenario modeling, and resource forecasting; enable robust portfolio prioritization and reporting.
- Standardization & Governance: Standardize ways of working in alignment with IT Operating Model; champion test automation, resilient operations, information security, and technology governance for clinical and DSSE platforms.
Qualifications
- Required: Advanced degree in Information Technology, Data Science, Computer Science, or related field with specialized knowledge in clinical development and analytics.
- 12–15+ years in life-sciences technology with 5–8+ years leading delivery for Clinical platforms in GxP environments.
- Deep expertise in 21 CFR Part 11, EU Annex 11, ICH E6(R2); demonstrated inspection-readiness leadership and strong CSV/CSA practices.
- Demonstrated vendor/SOW management with major platform providers (e.g., Veeva, Medidata).
- Strong program/portfolio leadership across complex multi-workstream initiatives; fluency in Agile and product operating models.
- Excellent executive communication and stakeholder engagement; strong analytical and problem-solving skills with a track record of operational excellence and innovation.
Preferred
- Experience with RBQM/centralized monitoring (e.g., CluePoints).
- Knowledge of CDISC standards, E2B(R3), portfolio analytics, and data visualization.
- Working knowledge of integration patterns (e.g., Boomi), cloud (AWS), automated testing, and data governance in regulated environments.