Senior Director, Clinical Pharmacology

Role: Senior Director, Clinical Pharmacology at a biopharma focused on rare neuroendocrine diseases, responsible for shaping and executing clinical pharmacology strategies across early and late-phase programs involving small molecules and peptides. Responsibilities include designing, implementing, and interpreting pharmacology studies (Ph 1-3), supporting dose selection, exposure-response modeling, and combination therapies; leading regulatory submissions and interactions; overseeing CROs and pharmacometric vendors; and collaborating with cross-functional teams in clinical development, regulatory affairs, biostatistics, and non-clinical sciences. The role involves strategic leadership and operational execution, with a focus on rare disease, pediatric extrapolation, and global regulatory compliance. Qualifications: Ph.D., Pharm.D., or equivalent in Clinical Pharmacology or related field; 12+ years in industry, with proven experience supporting global regulatory submissions and working in early and late-phase development; expertise in pharmacokinetics, pharmacodynamics, modeling/simulation tools (e.g., NONMEM, Phoenix WinNonlin) desirable. Preferred experience includes rare disease, combination therapy, obesity, metabolic, endocrinology, or pediatric development. The position reports to the CMO, requires hybrid work in Boston with some travel, and offers an estimated salary range of $210,000-$300,000.