Senior Director, Clinical Pharmacology
Centessa Pharmaceuticals
June 25, 2026
Remote
United States
Clinical Research and Development
Description of Role
Senior Director, Clinical Pharmacology to provide scientific and strategic leadership for clinical pharmacology across a neuroscience pipeline spanning early development through late-stage and registrational programs.
Key Responsibilities
- Lead clinical pharmacology strategy for CNS/neuroscience programs from first-in-human through registrational and post-marketing stages
- Design, execute, and interpret clinical pharmacology studies (FIH, MAD, DDI, biopharmaceutics, patient studies)
- Drive dose selection/optimization integrating PK, PD, safety, efficacy, and CNS-specific biomarkers
- Lead model-informed drug development (population PK, PK/PD, exposure–response analyses)
- Guide CNS exposure, brain penetration, target engagement, and translational biomarker strategies
- Serve as clinical pharmacology lead on program teams and trial working groups
- Author/oversee clinical pharmacology sections of regulatory documents (INDs, CTAs, IBs, NDAs)
- Represent clinical pharmacology in FDA and other global health authority interactions
- Partner with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs
- Oversee CROs/external vendors; ensure timely communication of results
- Contribute to portfolio strategy, prioritization, risk mitigation, and long-range planning
- Mentor clinical pharmacology talent; ensure submission-ready documentation
Qualifications
- PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or related field
- 8–12+ years clinical pharmacology experience in biopharma with impact on clinical drug development
- Strong PK/PD, PK/PD integration, exposure–response, and DDI expertise
- Experience with population PK/mechanistic PK/PD modeling for CNS dose selection
- Proficiency with NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent
- Experience authoring clinical pharmacology components of IND/CTA/NDA submissions and interacting with authorities
- Strong translational PK/CNS exposure and biomarker integration knowledge
- Excellent communication, collaboration, and leadership in a matrixed, fast-paced environment
Compensation/Benefits (if included)
- Base salary range: $270,000–$295,000; discretionary annual bonus; 401(k); medical/dental/vision/life insurance; paid time off; health and wellness program.
Work Location
- Remote (US), occasional travel.
Senior Director, Clinical Pharmacology to provide scientific and strategic leadership for clinical pharmacology across a neuroscience pipeline spanning early development through late-stage and registrational programs.
Key Responsibilities
- Lead clinical pharmacology strategy for CNS/neuroscience programs from first-in-human through registrational and post-marketing stages
- Design, execute, and interpret clinical pharmacology studies (FIH, MAD, DDI, biopharmaceutics, patient studies)
- Drive dose selection/optimization integrating PK, PD, safety, efficacy, and CNS-specific biomarkers
- Lead model-informed drug development (population PK, PK/PD, exposure–response analyses)
- Guide CNS exposure, brain penetration, target engagement, and translational biomarker strategies
- Serve as clinical pharmacology lead on program teams and trial working groups
- Author/oversee clinical pharmacology sections of regulatory documents (INDs, CTAs, IBs, NDAs)
- Represent clinical pharmacology in FDA and other global health authority interactions
- Partner with DMPK, Translational Sciences, Clinical Development, Biomarkers, Biostatistics, CMC, and Regulatory Affairs
- Oversee CROs/external vendors; ensure timely communication of results
- Contribute to portfolio strategy, prioritization, risk mitigation, and long-range planning
- Mentor clinical pharmacology talent; ensure submission-ready documentation
Qualifications
- PhD, PharmD, or MD in Clinical Pharmacology, Pharmacokinetics, Pharmaceutical Sciences, or related field
- 8–12+ years clinical pharmacology experience in biopharma with impact on clinical drug development
- Strong PK/PD, PK/PD integration, exposure–response, and DDI expertise
- Experience with population PK/mechanistic PK/PD modeling for CNS dose selection
- Proficiency with NONMEM, R, Phoenix WinNonlin, SimCyp, or equivalent
- Experience authoring clinical pharmacology components of IND/CTA/NDA submissions and interacting with authorities
- Strong translational PK/CNS exposure and biomarker integration knowledge
- Excellent communication, collaboration, and leadership in a matrixed, fast-paced environment
Compensation/Benefits (if included)
- Base salary range: $270,000–$295,000; discretionary annual bonus; 401(k); medical/dental/vision/life insurance; paid time off; health and wellness program.
Work Location
- Remote (US), occasional travel.