Senior Director, Clinical Development
Tango Therapeutics
August 12, 2026
On-site
Boston, MA
Clinical Research and Development
Responsibilities
- Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering cross-functionally to create and implement clinical development plans
- Provide medical and scientific leadership for development programs and serve as the clinical expert
- Design, author, and oversee study protocols, protocol amendments, investigator brochures, and other clinical documents per project plans, global regulations, ICH/GCP, and Good Medical Practice
- Serve as primary clinical lead for study investigators and key opinion leaders (KOLs)
- Lead clinical contributions to regulatory submissions (INDs, CTAs, NDA/MAA) and Health Authority interactions
- Act as Medical Monitor and/or oversee external Medical Monitors to ensure appropriate medical oversight and patient safety
- Provide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluation
- Partner with Clinical Operations, Clinical Pharmacology, Biometrics, Regulatory Affairs, Drug Safety, Data Management, Quality, and Translational Sciences
- Analyze and interpret clinical trial data; communicate findings via regulatory submissions, scientific publications, medical congress presentations, and internal reviews
- Lead responses to Health Authorities, Ethics Committees, and Institutional Review Boards
- Contribute to portfolio strategy, development planning, and other initiatives as needed
Qualifications
- MD required; board certification/eligibility in Medical Oncology, Hematology/Oncology, or related specialty strongly preferred
- 5+ years clinical development experience in biotech/pharma, including leading oncology development programs
- Experience designing, executing, interpreting, and reporting oncology clinical trials (targeted therapies, small molecules, and/or immuno-oncology)
- Experience with late-stage development and NDA/BLA/MAA submissions and Health Authority interactions
- Strong biological/translational oncology knowledge (molecular biology, cancer genetics, immunology, precision medicine)
- Ability to lead and influence cross-functional teams in a matrixed organization
- Excellent strategic, organizational, and project leadership; can balance planning and hands-on execution
- Strong problem-solving and ability to identify innovative approaches
- Exceptional communication/presentation skills with senior leaders, investigators, KOLs, and regulators
- Collaborative, team-oriented, results-driven leadership
- Flexible, resourceful, entrepreneurial mindset in a fast-paced environment
Salary range
- $274,400—$411,600 USD
- Lead the clinical development strategy and execution for assigned clinical-stage oncology asset(s), partnering cross-functionally to create and implement clinical development plans
- Provide medical and scientific leadership for development programs and serve as the clinical expert
- Design, author, and oversee study protocols, protocol amendments, investigator brochures, and other clinical documents per project plans, global regulations, ICH/GCP, and Good Medical Practice
- Serve as primary clinical lead for study investigators and key opinion leaders (KOLs)
- Lead clinical contributions to regulatory submissions (INDs, CTAs, NDA/MAA) and Health Authority interactions
- Act as Medical Monitor and/or oversee external Medical Monitors to ensure appropriate medical oversight and patient safety
- Provide strategic oversight of adverse event review, safety monitoring, protocol compliance, and clinical data evaluation
- Partner with Clinical Operations, Clinical Pharmacology, Biometrics, Regulatory Affairs, Drug Safety, Data Management, Quality, and Translational Sciences
- Analyze and interpret clinical trial data; communicate findings via regulatory submissions, scientific publications, medical congress presentations, and internal reviews
- Lead responses to Health Authorities, Ethics Committees, and Institutional Review Boards
- Contribute to portfolio strategy, development planning, and other initiatives as needed
Qualifications
- MD required; board certification/eligibility in Medical Oncology, Hematology/Oncology, or related specialty strongly preferred
- 5+ years clinical development experience in biotech/pharma, including leading oncology development programs
- Experience designing, executing, interpreting, and reporting oncology clinical trials (targeted therapies, small molecules, and/or immuno-oncology)
- Experience with late-stage development and NDA/BLA/MAA submissions and Health Authority interactions
- Strong biological/translational oncology knowledge (molecular biology, cancer genetics, immunology, precision medicine)
- Ability to lead and influence cross-functional teams in a matrixed organization
- Excellent strategic, organizational, and project leadership; can balance planning and hands-on execution
- Strong problem-solving and ability to identify innovative approaches
- Exceptional communication/presentation skills with senior leaders, investigators, KOLs, and regulators
- Collaborative, team-oriented, results-driven leadership
- Flexible, resourceful, entrepreneurial mindset in a fast-paced environment
Salary range
- $274,400—$411,600 USD