Senior Director, Biostatistics

Role: Senior Director of Biostatistics leading statistical activities for clinical development at Spyre Therapeutics, focusing on immunology therapies for IBD and rheumatic diseases. Responsibilities: oversee biostatistics teams, contribute to study design, develop statistical analysis plans, author protocols, and support regulatory interactions; ensure robust analysis and data quality; manage vendors and cross-functional collaboration; promote innovative statistical methods and support global health authority communications. Requirements: PhD in Biostatistics or related field; 10-12+ years in biostatistics within pharma/biotech/CRO sectors; extensive experience with clinical trial methodologies, regulatory submissions, SAS/R, and data standards like SDTM/ADaM/CDISC; strong leadership and communication skills. Preferred: Bayesian methods knowledge; proven track record in global regulatory environments; experience supporting therapeutics in immunology, especially IBD or rheumatic diseases. High-Value: Leadership in late-stage (Phases 2-3) clinical trials; supporting biologics and antibody combination programs; biometrics vendor oversight; remote work with occasional meetings; competitive salary range ($275K-$290K). Collaboration includes clinical development, data management, regulatory, pharmacovigilance, and external vendors.