Senior Director, Biostatistics
Bicycle Therapeutics
July 02, 2026
Remote friendly (Lexington, MA)
United States
$235,000 - $295,000 USD yearly
Clinical Research and Development
Job Description
Your mission is to provide expert strategic and statistical leadership for Bicycle's clinical development portfolio, leading a team of biostatisticians to shape study designs, guide program strategy, ensure clinical data integrity, and translate complex data into actionable insights.
Responsibilities
- Lead, coach, and mentor biostatisticians; foster high performance and psychological safety.
- Set biostatistics goals and priorities aligned with departmental and organizational objectives.
- Serve as program-level biostatistical lead for key development assets; shape the clinical development plan.
- Collaborate with Medical, Clinical Research, and Regulatory Affairs to support data-driven clinical decisions.
- Represent Biostatistics in regulatory interactions; provide statistical expertise for meetings and author regulatory document sections.
- Provide senior oversight for study-level biostatistical activities (including vendors) for quality and timeliness.
- Apply advanced statistical methods (e.g., modeling and simulation) for study design, analysis, and interpretation.
- Review and approve key statistical documents (protocols, Statistical Analysis Plans) for fitness for purpose.
Qualifications / Skills
- Senior biostatistics leadership experience in biopharma, with deep focus on oncology clinical trials.
- Proven people management experience leading high-performing technical teams.
- Ability to develop and execute statistical strategy and translate complex data into impactful insights.
- Expert knowledge of advanced statistical methods and GCP/regulatory guidelines across all clinical development phases.
- Proficiency with R and/or SAS; strong understanding of simulation and modeling.
Benefits (as stated)
- Flexible working environment.
- Competitive reward including annual company bonus.
- Medical, dental, and vision insurance (100% premiums for eligible employees and families).
- Health and Dependent Care Flexible Spending Accounts.
- 401(k) with 4% company match and immediate vesting.
- Eligibility for up to 23 paid time off days/year plus option to buy up to 5 additional days.
- Employee assistance program; employee recognition schemes; 10 company holidays.
- Competitive family leave policy.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Compensation
- Salary range: $235,000–$295,000.
Your mission is to provide expert strategic and statistical leadership for Bicycle's clinical development portfolio, leading a team of biostatisticians to shape study designs, guide program strategy, ensure clinical data integrity, and translate complex data into actionable insights.
Responsibilities
- Lead, coach, and mentor biostatisticians; foster high performance and psychological safety.
- Set biostatistics goals and priorities aligned with departmental and organizational objectives.
- Serve as program-level biostatistical lead for key development assets; shape the clinical development plan.
- Collaborate with Medical, Clinical Research, and Regulatory Affairs to support data-driven clinical decisions.
- Represent Biostatistics in regulatory interactions; provide statistical expertise for meetings and author regulatory document sections.
- Provide senior oversight for study-level biostatistical activities (including vendors) for quality and timeliness.
- Apply advanced statistical methods (e.g., modeling and simulation) for study design, analysis, and interpretation.
- Review and approve key statistical documents (protocols, Statistical Analysis Plans) for fitness for purpose.
Qualifications / Skills
- Senior biostatistics leadership experience in biopharma, with deep focus on oncology clinical trials.
- Proven people management experience leading high-performing technical teams.
- Ability to develop and execute statistical strategy and translate complex data into impactful insights.
- Expert knowledge of advanced statistical methods and GCP/regulatory guidelines across all clinical development phases.
- Proficiency with R and/or SAS; strong understanding of simulation and modeling.
Benefits (as stated)
- Flexible working environment.
- Competitive reward including annual company bonus.
- Medical, dental, and vision insurance (100% premiums for eligible employees and families).
- Health and Dependent Care Flexible Spending Accounts.
- 401(k) with 4% company match and immediate vesting.
- Eligibility for up to 23 paid time off days/year plus option to buy up to 5 additional days.
- Employee assistance program; employee recognition schemes; 10 company holidays.
- Competitive family leave policy.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Compensation
- Salary range: $235,000–$295,000.