Senior Director, Biostatistics
Bicycle Therapeutics
August 21, 2026
Remote friendly (Lexington, MA)
United States
$235,000 - $295,000 USD yearly
Clinical Research and Development
Your mission is to provide expert strategic and statistical leadership for Bicycle's clinical development portfolio. You will lead a team of biostatisticians, shaping study designs, guiding program strategy, and ensuring the integrity of clinical data.
Responsibilities:
- Lead, coach, and mentor biostatisticians; foster high performance and psychological safety.
- Set biostatistics goals and priorities aligned with departmental and organizational objectives.
- Serve as program-level biostatistical lead for key development assets.
- Collaborate with Medical, Clinical Research, and Regulatory Affairs for data-driven decisions.
- Represent Biostatistics in regulatory interactions; provide statistical expertise for meetings and author regulatory document sections.
- Provide senior oversight for study-level biostatistical activities (including vendors).
- Apply advanced statistical methods (modeling and simulation) for study design, analysis, and interpretation.
- Review and approve key statistical documents (e.g., protocols, Statistical Analysis Plans) to ensure fit for purpose.
Qualifications / Skills:
- Senior biostatistics leadership experience in biopharma, with a focus on oncology clinical trials.
- Proven people management experience.
- Ability to develop and execute statistical strategy and translate data into actionable insights.
- Expert knowledge of advanced statistical methods and GCP across all phases of clinical development.
- Proficiency in R and/or SAS; deep understanding of modeling and simulation techniques.
Benefits (as listed):
- Flexible working environment
- Competitive reward including annual company bonus
- Medical, dental, vision insurance (100% premiums covered by Company)
- Health and Dependent Care Flexible Spending Accounts
- 401(k) plan with 4% company match and immediate vesting
- Up to 23 paid time off days/year (plus option to buy up to 5)
- Employee assistance program; employee recognition schemes; 10 company holidays
- Competitive Family Leave Policy
- Eligibility for option grant to subscribe to shares in Bicycle Therapeutics plc
Compensation:
- Salary range: $235,000–$295,000
Responsibilities:
- Lead, coach, and mentor biostatisticians; foster high performance and psychological safety.
- Set biostatistics goals and priorities aligned with departmental and organizational objectives.
- Serve as program-level biostatistical lead for key development assets.
- Collaborate with Medical, Clinical Research, and Regulatory Affairs for data-driven decisions.
- Represent Biostatistics in regulatory interactions; provide statistical expertise for meetings and author regulatory document sections.
- Provide senior oversight for study-level biostatistical activities (including vendors).
- Apply advanced statistical methods (modeling and simulation) for study design, analysis, and interpretation.
- Review and approve key statistical documents (e.g., protocols, Statistical Analysis Plans) to ensure fit for purpose.
Qualifications / Skills:
- Senior biostatistics leadership experience in biopharma, with a focus on oncology clinical trials.
- Proven people management experience.
- Ability to develop and execute statistical strategy and translate data into actionable insights.
- Expert knowledge of advanced statistical methods and GCP across all phases of clinical development.
- Proficiency in R and/or SAS; deep understanding of modeling and simulation techniques.
Benefits (as listed):
- Flexible working environment
- Competitive reward including annual company bonus
- Medical, dental, vision insurance (100% premiums covered by Company)
- Health and Dependent Care Flexible Spending Accounts
- 401(k) plan with 4% company match and immediate vesting
- Up to 23 paid time off days/year (plus option to buy up to 5)
- Employee assistance program; employee recognition schemes; 10 company holidays
- Competitive Family Leave Policy
- Eligibility for option grant to subscribe to shares in Bicycle Therapeutics plc
Compensation:
- Salary range: $235,000–$295,000