Senior Director, Biostatistics

Role: Senior leader responsible for strategic and statistical direction of Bicycle Therapeutics' clinical development, primarily focused on oncology assets. Responsibilities include leading, mentoring, and developing the biostatistics team; shaping statistical strategies for key development programs; collaborating with cross-functional teams including Medical, Clinical, and Regulatory; and representing biostatistics in regulatory interactions. The role involves providing technical oversight of study-level activities, applying advanced statistical methods, and ensuring high-quality, compliant documentation. Qualifications include extensive senior biostatistics experience within biopharma, especially in oncology clinical trials, with proven leadership, strategic planning, and regulatory expertise. Proficiency in statistical programming (e.g., R, SAS), modeling, and simulation is required. High-value specifics encompass leadership in a biotech setting developing Bicycle molecules, Bicycle Drug Conjugates targeting EphA2 and Nectin-4, working across multiple therapeutic areas, and engaging in all phases of clinical development, including regulatory submissions. The position is based in a hybrid model with three days onsite in Lexington, MA, and involves strategic influence across the organization's clinical pipeline, fostering innovation, collaboration, and mission-driven impact.