Senior Director, AIRx Biochemistry - In Vitro Biology Lead

Purpose:
Own the in vitro pharmacology cascade for all AIRx programs—define testing strategy, oversee CRO assay execution, and ensure high-quality, reproducible biochemical/cellular data that informs go/no-go decisions.

Responsibilities:
- Design and own the in vitro pharmacology cascade across AIRx project teams
- Define CRO assay specifications; provide scientific oversight; interpret biochemical and cellular data
- Integrate biochemical data into AI-enabled DMTA cycles; partner to close design loops
- Ensure data quality, reproducibility, and standardization across external biology partners; support ingestion/analysis via SAIL and Aedifica Fortis
- Contribute to safety, selectivity, and mechanistic profiling strategies with Safety and DMPK
- Provide scientific input to PRC presentations/governance forums
- Harmonize assay data across sources to support AI model training and insights
- Stay current on biochemistry literature and emerging assay technologies

Qualifications:
- PhD in biochemistry, pharmacology, or cell biology
- 12–15+ years drug discovery experience; hands-on biochemical and cell-based assay development/interpretation
- Track record managing externalized CRO biochemistry/pharmacology programs
- Ability to critically evaluate/integrate large in vitro datasets from multiple sources
- Experience in at least one Takeda Research therapeutic area

Preferred:
- AI/ML data analysis platforms (e.g., automated pipelines, TetraScience)
- Mechanistic/MoA-level characterization

Compensation & Benefits (U.S. base):
- $212,000.00–$333,190.00; medical/dental/vision, 401(k) match, disability, life insurance, tuition reimbursement, paid time off; sick time and vacation accrual.

Location/Work:
- Cambridge, MA (Hybrid)

Application:
- Submit an application via the “Apply” button; your information is processed per the application Privacy Notice/Terms of Use.