Senior Clinical Trial Manager (CTM)
Praxis Precision Medicines, Inc.
August 24, 2026
Remote
United States
Clinical Research and Development
Position Summary
This role will manage project management for the initiation, execution, and close out of domestic and international clinical studies, including study concept and design, feasibility assessments, study start-up, contract and budget oversight, data exchange, and support of data analysis and interpretation.
Primary Responsibilities
- Manage study activities from protocol concept to clinical study report, complying with Good Clinical Practice (GCP) and international regulations
- Manage strategic engagement with key collaborators
- Set up and oversee clinical trial trackers (regulatory documents, trial master file (TMF), startup progress, screening/enrollment, invoices/payments, project budgets, etc.)
- Contribute to IRB/EC and regulatory submissions
- Oversee TMF reviews to ensure completeness and inspection readiness
- Review documents to ensure adherence to Clinical Operations/project quality requirements (e.g., SOPs, work practices, training guides)
- Identify and mitigate study risks, escalating as necessary
- Implement best practices and continuous improvement plans in clinical development
Education and Professional Experience
- Bachelor’s degree in a scientific field (advanced degree a plus)
- 5+ years directly managing clinical trials in a Sponsor or CRO setting
- In-depth knowledge of clinical trial operations, ICH, GCP, and applicable regulatory requirements
- Experience directing clinical operations teams
- Experience working across multiple functions (Quality Assurance, Data Management, Biostats, Medical Writing, Safety, Clinical Supply, Finance)
Other Essentials / Key Success Factors
- Intellectual curiosity, innovation, creative problem solving
- Critical thinking in fast-paced projects; strong sense of urgency
- Self-motivated and collaborative
- Highly organized, detail-oriented; quality-focused
- Strong verbal and written communication
Annualized Base Salary: $168,000 USD - $188,000 USD
This role will manage project management for the initiation, execution, and close out of domestic and international clinical studies, including study concept and design, feasibility assessments, study start-up, contract and budget oversight, data exchange, and support of data analysis and interpretation.
Primary Responsibilities
- Manage study activities from protocol concept to clinical study report, complying with Good Clinical Practice (GCP) and international regulations
- Manage strategic engagement with key collaborators
- Set up and oversee clinical trial trackers (regulatory documents, trial master file (TMF), startup progress, screening/enrollment, invoices/payments, project budgets, etc.)
- Contribute to IRB/EC and regulatory submissions
- Oversee TMF reviews to ensure completeness and inspection readiness
- Review documents to ensure adherence to Clinical Operations/project quality requirements (e.g., SOPs, work practices, training guides)
- Identify and mitigate study risks, escalating as necessary
- Implement best practices and continuous improvement plans in clinical development
Education and Professional Experience
- Bachelor’s degree in a scientific field (advanced degree a plus)
- 5+ years directly managing clinical trials in a Sponsor or CRO setting
- In-depth knowledge of clinical trial operations, ICH, GCP, and applicable regulatory requirements
- Experience directing clinical operations teams
- Experience working across multiple functions (Quality Assurance, Data Management, Biostats, Medical Writing, Safety, Clinical Supply, Finance)
Other Essentials / Key Success Factors
- Intellectual curiosity, innovation, creative problem solving
- Critical thinking in fast-paced projects; strong sense of urgency
- Self-motivated and collaborative
- Highly organized, detail-oriented; quality-focused
- Strong verbal and written communication
Annualized Base Salary: $168,000 USD - $188,000 USD