Senior Clinical Research Scientist II
Caribou Biosciences
August 21, 2026
Remote friendly (Berkeley, CA)
United States
Clinical Research and Development
Summary:
The Senior Clinical Research Scientist II leads study-level activities and contributes to clinical strategy for early-phase allogeneic CAR-T therapies for hematologic malignancies.
Responsibilities:
- Lead clinical study execution (planning, conduct, data review, reporting) for Phase I/II trials in hematologic malignancies.
- Own ongoing clinical data review to ensure patient safety and data integrity; identify trends and drive data-informed decisions.
- Lead safety monitoring, including review of adverse events and CAR-T toxicities (CRS, ICANS) and contribute to dose escalation decisions.
- Drive cross-functional collaboration with Clinical Operations, Translational Sciences, Data Management, Biostatistics, Regulatory, and CMC.
- Lead authorship of key study documents (protocols, Investigator’s Brochures, clinical study reports, regulatory documents, safety narratives).
- Integrate clinical and translational data (cell expansion, persistence, biomarker data) to inform program strategy.
- Contribute to regulatory strategy and submissions (IND-related documents and health authority responses).
- Serve as scientific lead at the study level (investigators, CROs, KOLs).
- Support publications, abstracts, and conference presentations.
- Ensure compliance with GCP, internal SOPs, and regulatory requirements.
Qualifications:
- PhD/PharmD (5+ years); MA/MS/MSN (8+ years); BA/BS/BSN (10+ years) in clinical development.
- Experience in hematology-oncology drug development.
- Experience with CAR-T or cell therapy development.
- Ownership of clinical studies (preferably early phase).
- Strong scientific writing and communication.
- GCP and regulatory requirements experience.
- Clinical data review/interpretation (including data listings).
- Ability to analyze complex clinical and biomarker data.
- Travel ~30% based on business needs.
Nice-to-haves:
- Experience in a fast-paced biotech environment.
- Experience with product launch or late-stage development.
Benefits:
- Competitive salary/bonus/equity; paid vacation; medical/dental/vision; 401(k) with match; ESPP; tuition reimbursement.
The Senior Clinical Research Scientist II leads study-level activities and contributes to clinical strategy for early-phase allogeneic CAR-T therapies for hematologic malignancies.
Responsibilities:
- Lead clinical study execution (planning, conduct, data review, reporting) for Phase I/II trials in hematologic malignancies.
- Own ongoing clinical data review to ensure patient safety and data integrity; identify trends and drive data-informed decisions.
- Lead safety monitoring, including review of adverse events and CAR-T toxicities (CRS, ICANS) and contribute to dose escalation decisions.
- Drive cross-functional collaboration with Clinical Operations, Translational Sciences, Data Management, Biostatistics, Regulatory, and CMC.
- Lead authorship of key study documents (protocols, Investigator’s Brochures, clinical study reports, regulatory documents, safety narratives).
- Integrate clinical and translational data (cell expansion, persistence, biomarker data) to inform program strategy.
- Contribute to regulatory strategy and submissions (IND-related documents and health authority responses).
- Serve as scientific lead at the study level (investigators, CROs, KOLs).
- Support publications, abstracts, and conference presentations.
- Ensure compliance with GCP, internal SOPs, and regulatory requirements.
Qualifications:
- PhD/PharmD (5+ years); MA/MS/MSN (8+ years); BA/BS/BSN (10+ years) in clinical development.
- Experience in hematology-oncology drug development.
- Experience with CAR-T or cell therapy development.
- Ownership of clinical studies (preferably early phase).
- Strong scientific writing and communication.
- GCP and regulatory requirements experience.
- Clinical data review/interpretation (including data listings).
- Ability to analyze complex clinical and biomarker data.
- Travel ~30% based on business needs.
Nice-to-haves:
- Experience in a fast-paced biotech environment.
- Experience with product launch or late-stage development.
Benefits:
- Competitive salary/bonus/equity; paid vacation; medical/dental/vision; 401(k) with match; ESPP; tuition reimbursement.