Responsibilities:
- Design, execute, analyze, and troubleshoot in vitro experiments to characterize and validate antibody-retargeted viral vector designs, screening protocols, and performance.
- Perform basic molecular biology and protein analysis techniques (e.g., cloning, SDS-PAGE, Western blotting, ELISA, DNA extraction, PCR, qPCR, protein chromatography).
- Partner with the bioinformatics team to translate vector designs into screening platforms.
- Execute rAAV production protocols and apply knowledge of AAV biology to inform novel vector optimizations.
- Collaborate with cross-functional team members, analytical group collaborators, and core facilities across Research and Discovery.
- Participate in team meetings and prepare regular updates and presentations for departmental forums.
Qualifications:
- B.A./B.S. with 5+ years of relevant industry or academic experience.
- Preferred: M.S. in cell biology, molecular biology, biochemistry, protein purification, and/or antibodies.
- Required experience: mammalian cell culture; manipulation and purification of viruses and/or proteins; DNA isolation from tissues and cells; plasmid cloning; use of antibodies in various applications; maintenance of accurate, up-to-date electronic lab records.
- Desired: familiarity with key antibody properties, protein engineering, viral vector production, and research software (e.g., Microsoft Office, GraphPad Prism, Benchling, MacVector).