Senior Associate Scientist - Neurodegenerative Disease Research

Role Summary

Senior Associate Scientist - Neurodegenerative Disease Research. Location: Cambridge, MA.

Responsibilities

• Perform experiments and studies in support of neurodegenerative disease research projects and company drug discovery goals
• Design, execute, and troubleshoot experiments in both in vivo and in vitro settings
• Establish and optimize iPSC-derived neuronal and glial cell culture models for disease modeling and drug screening
• Analyze, interpret, and present experimental results to team members and project stakeholders
• Develop and maintain neurodegenerative disease models, including handling laboratory animals
• Conduct animal procedures including necropsy, various injection routes (IV, IP, SC), and assist with intracranial stereotaxic surgeries
• Perform cell culture techniques, qPCR, ELISA, and plate-based assays (MSD/SIMOA)
• Execute microscopy and cell-based imaging techniques to evaluate cellular phenotypes
• Integrate multi-omics and human biology data to guide target validation and model development
• Maintain detailed and accurate laboratory records following scientific rigor standards
• Collaborate effectively with team members and contribute to a positive team environment
• Support the development of new methodologies and approaches as needed

Qualifications

• Bachelor's Degree plus minimum 4 years of relevant research experience in an academic or biopharmaceutical setting OR Master's Degree plus minimum 1 year of relevant research experience
• Strong technical expertise in neuroscience research techniques
• Experience with in vivo models of neurodegenerative diseases, including animal handling, necropsy, and various injection routes (IV, IP, SC)
• Proficiency in cell culture techniques, including 2D and 3D culture systems
• Experience integrating human biology datasets (e.g., genomics, transcriptomics) into experimental workflows
• Proficiency in qPCR, ELISA, and plate-based assays (MSD/SIMOA)
• Experience with microscopy and cell-based imaging techniques
• Demonstrated ability to work in a team environment and collaborate effectively
• Excellent documentation and record-keeping skills
• Strong analytical and problem-solving abilities
• Ability to prioritize and organize work to meet project deadlines
• Knowledge of laboratory safety procedures and good laboratory practices

Skills

• Neuroscience research techniques
• In vivo and in vitro model development
• iPSC-derived culture models
• qPCR, ELISA, MSD/SIMOA
• Microscopy and cell imaging
• Data integration from genomics/transcriptomics
• Laboratory record-keeping and documentation

Education

• As listed in Qualifications