Senior Associate Scientist

Role Summary

Senior Associate Scientist positioned to develop and characterize cellular and animal models to test novel therapeutics for neurodegenerative diseases. Involves collecting disease-relevant tissue from animal models, downstream processing, and presenting data in a collaborative, cross-functional environment. Local telecommuting permitted up to 1 day per week.

Responsibilities

• Develop and characterize cellular and mouse models of neurological and neurodegenerative disease.
• Collect disease-relevant tissue from animal models and perform downstream processing including biochemical analysis, tissue sectioning, immunohistochemistry, and microscopy.
• Design and implement cell-based assays and other technologies to understand mechanisms of neurodegeneration.
• Analyze and evaluate data; present findings internally and externally; contribute to collaborative discussions.
• Engage in research studies to understand biology behind various neurodegenerative diseases (e.g., ALS).

Qualifications

• Required: Bachelor’s degree in Biology, Molecular Biology, Neuroscience, Biotechnology or related field and 1 year of biotechnology industry experience.
• Experience with:
  • Development and characterization of novel cellular and mouse models of neurological/neurodegenerative disease.
  • Handling neonatal and adult mice; mouse anatomy; intracerebroventricular (ICV) injection of AAV into neonatal pups; mouse dissection and CNS tissue microdissection.
  • Processing cell/tissue samples for biochemical analysis (Western blot, ProteinSimple Wes/PeggySue, ELISA, MSD); DNA/RNA isolation; qPCR.
  • Downstream tissue processing including sectioning, immunostaining, immunohistochemistry, and advanced microscopy (confocal, high-throughput imaging such as OperaPhoenix).
  • In vitro cell culture using transformed lines and human iPSCs, including neuronal differentiation.
  • Data analysis using Halo, GraphPad Prism, Excel, PowerPoint; presenting data in presentations.

Skills

• Strong data analysis and presentation skills; ability to contribute to cross-functional teams.
• Proficiency with immunohistochemistry, microscopy, and biochemical assay workflows.
• Experience with neuronal differentiation from iPSCs and mouse model work.

Education

• Bachelor’s degree in Biology, Molecular Biology, Neuroscience, Biotechnology or related field.