Senior Associate Scientist

Role Summary

We are seeking a motivated scientist to join the High Throughput Antibody Screening and Biomolecular Interaction Group within the Therapeutic Proteins team. As a Senior Associate Scientist, you will support the VelocImmune fully-human antibody pipeline by implementing methods to characterize protein interaction kinetics and biochemical properties using SPR, BLI, ITC, and other analytical technologies. Responsibilities include antibody characterization, method development, and analytical support for biologics development, troubleshooting, tabulating results, and presenting findings to the group and other departments.

Responsibilities

• Antibody characterization, method development, and analytical support for biologics development using biochemical and biophysical methods.
• Troubleshooting established test methods used in development and release testing of screening reagents.
• Tabulate results and write summary reports of assay development.
• Present findings at group and interdepartmental meetings.
• Maintain lab supplies and equipment.
• Produce and maintain accurate records.

Qualifications

• Required: BS with 6+ yrs or MS degree with 3+ yrs proven experience. Solid understanding in one or more of the following areas: structural biology, biophysics, or chemical biology. The candidate is expected to be able to follow verbal and written instructions, be self-motivated, resourceful, and proactive, in addition to possessing excellent organizational, interpersonal, and problem solving skills. Knowledge and experience in using biophysical methodologies such as Biacore, Octet, or ITC to study protein/small molecule or protein/protein interactions and binding kinetics. Good hands-on experience in protein chemistry such as (HPLC, FPLC, ion-exchange, affinity, size exclusion chromatography, and protein conjugation chemistry) or protein analysis (SDS-PAGE, Western-blot, ELISA). Highly motivated and able to work productively in a fast-paced team environment. Excellent communication skills.
• Preferred: Iso-Thermal Calorimetry.