Senior Advisor – Discovery ADME Project Leader
Eli Lilly and Company
6 hours ago
Remote friendly (Indianapolis, IN)
United States
$181,500 - $266,200 USD yearly
Clinical Research and Development
Job Title: Senior Advisor – Discovery ADME Project Leader
What You Will Do
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations and modeling to support dose selection, PK/PD design, efficacy and safety studies.
- Define stage-, modality-, and issue-appropriate screening, decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design and optimization through data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME strategy and science single-point-of-accountability on cross-functional program teams; translate ADME findings into actional design and test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance discussions and leadership reviews.
- Implement procedures, assay innovation, and automation where appropriate; drive innovation in data reporting, knowledge management, and decision frameworks; seek AI/agentic tools to pipeline, interpret, and share results.
- Maintain inspection-ready documentation and alignment with regulatory expectations.
- Mentor, teach, and grow junior scientists; contribute to functional capability building.
Qualifications
- PhD in Pharmaceutical Sciences, pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related scientific field.
- Minimum 3+ years post-graduation industry experience in drug discovery; experience leading discovery teams and the Design, Make, Test, Analyze life cycle/flywheel.
- 3+ years experience in ADME/PKPD.
Preferred Qualifications
- Medicinal chemistry and Toxicology principles.
- Exceptional written and verbal communication; ability to navigate ambiguity and/or global cross-functional collaboration.
- Ability to translate complex technical concepts into strategic value for senior leadership and partners.
Benefits/Compensation (if applicable)
- Company bonus (for full-time equivalent employees).
- Eligibility for medical, dental, vision, prescription drug benefits; flexible benefits; life insurance and death benefits; certain time off and leave of absence benefits; well-being benefits; 401(k); pension; vacation benefits.
Geography
- Indianapolis, IN; Louisville, CO; or Boston, MA.
What You Will Do
- Keep Safety as a priority.
- Develop and execute integrated preclinical ADME strategies aligned with discovery stage, target product profile (TPP), design hypotheses, and regulatory expectations.
- Integrate ADME and pharmacology to enable translational simulations and modeling to support dose selection, PK/PD design, efficacy and safety studies.
- Define stage-, modality-, and issue-appropriate screening, decision funnels (in silico, in vitro, in vivo to translational modeling).
- Guide compound design and optimization through data-driven principles (clearance, permeability, solubility, DDI risk, transporter liabilities).
- Serve as ADME strategy and science single-point-of-accountability on cross-functional program teams; translate ADME findings into actional design and test hypotheses.
- Collaborate with Medicinal Chemistry, DMPK, Toxicology, Pharmacology, and other Discovery functions; contribute to go/no-go decisions using quantitative PK/PD, IVIVE, and mechanistic interpretation.
- Represent ADME in portfolio governance discussions and leadership reviews.
- Implement procedures, assay innovation, and automation where appropriate; drive innovation in data reporting, knowledge management, and decision frameworks; seek AI/agentic tools to pipeline, interpret, and share results.
- Maintain inspection-ready documentation and alignment with regulatory expectations.
- Mentor, teach, and grow junior scientists; contribute to functional capability building.
Qualifications
- PhD in Pharmaceutical Sciences, pharmacokinetics, Pharmacometrics, Systems Pharmacology, Preclinical/Clinical Pharmacology, Drug Metabolism, Toxicology, Chemical Biology, or related scientific field.
- Minimum 3+ years post-graduation industry experience in drug discovery; experience leading discovery teams and the Design, Make, Test, Analyze life cycle/flywheel.
- 3+ years experience in ADME/PKPD.
Preferred Qualifications
- Medicinal chemistry and Toxicology principles.
- Exceptional written and verbal communication; ability to navigate ambiguity and/or global cross-functional collaboration.
- Ability to translate complex technical concepts into strategic value for senior leadership and partners.
Benefits/Compensation (if applicable)
- Company bonus (for full-time equivalent employees).
- Eligibility for medical, dental, vision, prescription drug benefits; flexible benefits; life insurance and death benefits; certain time off and leave of absence benefits; well-being benefits; 401(k); pension; vacation benefits.
Geography
- Indianapolis, IN; Louisville, CO; or Boston, MA.