Scientist - Targeted Protein Degradation

Role Summary

Scientist in Amgen's Targeted Protein Degradation function within the Induced Proximity Platform (IPP). You will help build phenotypic-based screening platforms to identify Molecular Glue degraders for high-value targets, contributing to drug discovery programs across Oncology, Cardiometabolic Disorders, Inflammation, and Rare Diseases. You will work in a collaborative environment where biology, chemistry, and data science converge to deliver transformative medicines for patients.

Responsibilities

• Execute experiments to identify, characterize, and optimize molecular glue degraders for therapeutic targets.
• Perform biochemical and cellular assays to investigate degrader activity and mechanisms of action.
• Collaborate with cross-functional partners in medicinal chemistry, biology, and data science to advance discovery programs.
• Assist in the design and implementation of phenotypic-based screening platforms for induced proximity drug discovery.
• Develop and validate cell-based assays that capture functional outcomes relevant to disease biology (HiBiT, NanoBiT, cell viability assays).
• Support screening campaigns using high-throughput or high-content approaches, in partnership with automation and data teams.
• Work closely with colleagues across IPP to share results and integrate findings into broader discovery efforts.
• Present research progress in team meetings and contribute to technical reports and publications.
• Participate in a collaborative, fast-paced research culture that values creativity, rigor, and teamwork.

Qualifications

• Required: Doctorate degree
• Required: Master’s degree and 2 years of directly related experience
• Required: Bachelor’s degree and 4 years of directly related experience
• Preferred: Master’s degree in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, Pharmacology, or a related field
• Preferred: 1+ years of relevant industry experience (biotechnology or pharmaceutical research)
• Preferred: Hands-on experience with cellular and molecular biology techniques (cell culture, transfection, Western blotting, flow cytometry, ELISA, or related methods)
• Preferred: Experience in cell-based assay development and/or phenotypic screening approaches
• Preferred: Familiarity with protein degradation or induced proximity biology
• Preferred: Exposure to automation or high-throughput technologies
• Preferred: Strong data analysis skills, with the ability to interpret, and efficiently report, experimental results and troubleshoot assays
• Preferred: Effective communication skills, both written and verbal, with the ability to work in a team-oriented environment

Education

• Doctorate degree
• Master’s degree
• Bachelor’s degree