Scientist - Targeted Protein Degradation

Role Summary

Scientist - Targeted Protein Degradation. Contribute to drug discovery programs within Amgen’s Induced Proximity Platform (IPP) by building phenotypic-based screening platforms to identify Molecular Glues for high-value targets, integrating molecular biology, cell biology, and chemical biology.

Responsibilities

• Execute experiments to identify, characterize, and optimize molecular glue degraders for therapeutic targets.
• Perform biochemical and cellular assays to investigate degrader activity and mechanisms of action.
• Collaborate with cross-functional partners in medicinal chemistry, biology, and data science to advance discovery programs.
• Assist in the design and implementation of phenotypic-based screening platforms for induced proximity drug discovery.
• Develop and validate cell-based assays that capture functional outcomes relevant to disease biology (HiBiT, NanoBiT, Cell viability assays).
• Support screening campaigns using high-throughput or high-content approaches, in partnership with automation and data teams.
• Work closely with colleagues across IPP to share results and integrate findings into broader discovery efforts.
• Present research progress in team meetings and contribute to technical reports and publications.
• Participate in a collaborative, fast-paced research culture that values creativity, rigor, and teamwork.

Qualifications

• Basic Qualifications:
  • Doctorate degree
  • Or Master‚Äôs degree and 2 years of directly related experience
  • Or Bachelor‚Äôs degree and 4 years of directly related experience
• Preferred Qualifications:
  • Master‚Äôs degree in Cell Biology, Molecular Biology, Chemical Biology, Biochemistry, Pharmacology, or a related field.
  • 1+ years of relevant industry experience (biotechnology or pharmaceutical research).
  • Hands-on experience with cellular and molecular biology techniques (e.g., cell culture, transfection, Western blotting, flow cytometry, ELISA, or related methods).
  • Experience in cell-based assay development and/or phenotypic screening approaches.
  • Familiarity with protein degradation or induced proximity biology.
  • Exposure to automation or high-throughput technologies.
  • Strong data analysis skills, with the ability to interpret, and efficiently report, experimental results and troubleshoot assays.
  • Effective communication skills, both written and verbal, with the ability to work in a team-oriented environment.

Skills

• Cell biology
• Biochemical and cellular assays
• Phenotypic screening
• Molecular biology techniques
• Data analysis and interpretation
• Team collaboration and communication

Education

• Doctorate or Master‚Äôs/Bachelor‚Äôs with relevant experience as specified in qualifications.